Aminosyn HF 8% (Amino Acid Injection Hepatic Formula) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 24, 2012

Aminosyn HF 8%

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AMINOSYN®-HF 8%
(amino acid) Injection

Flexible Plastic Container
Avoid exposure to light until use
Hepatic Formula

DRUG DESCRIPTION

Aminosyn-HF 8% (amino acid injection 8%) is a sterile, nonpyrogenic, hypertonic solution for intravenous infusion. The formulation is described below:

Aminosyn-HF 8% An Amino Acid Injection–Hepatic Formula Essential Amino Acids (mg/100 mL)

Isoleucine	900
Leucine	1,100
Lysine (acetate)*	610
Methionine	100
Phenylalanine	100
Threonine	450
Tryptophan	66
Valine	840
*Amount cited is for lysine alone and does not include the acetate salt.

Nonessential Amino Acids (mg/100 mL)

Alanine	770
Arginine	600
Cysteine HCl • H₂0	< 20
Glycine	900
Histidine	240
Proline	800
Serine	500

Electrolytes (mEq/Liter)

Sodium (Na⁺)	11
Phosphate (HPO⁼₄)	20^a
Acetate (C₂H₃O₂^-)^b	approx. 62^c
Chloride (Cl^-)	< 3
^a 10 mmoles P/L ^b Including ions for pH adjustment ^c From lysine acetate

Product Characteristics per 100 mL

Nitrogen	1.2g^d
Sodium Hydrosulfite	100mg^e
Phosphoric Acid	115mg
pH	6.4
pH Range	6.0 to 7.0^f
Osmolarity	768 mOsmol/Liter
Specific Gravity	1.02
^d 7.6g of protein equivalent ^e Added as the antioxidant ^f Adjusted with glacial acetic acid

The formulas for the individual amino acids present in Aminosyn–HF 8% are as follows:

Essential Amino Acids

Isoleucine	CH₃CH₂CH(CH₃)CH(NH₂)COOH
Leucine	(CH₃)₂CHCH₂CH(NH₂)COOH
Lysine (acetate)	H₂N(CH₂)₄CH(NH₂)COOH • CH₃COOH
Methionine	CH₃S(CH₂)₂CH(NH₂)COOH
Phenylalanine	CH2CH(NH₂)COOH
Threonine	CH₃CH(OH)CH(NH₂)COOH
Tryptophan	CH₂CH(NH₂)COOH
Valine	(CH₃)₂CHCH(NH₂)COOH

Nonessential Amino Acids

Alanine	CH₃CH(NH₂)COOH
Arginine	H₂NC(NH)NH(CH₂)₃CH(NH₂)COOH
Cysteine HCl • H₂0	HSCH₂CH(NH₂)COOH • HCl • H₂0
Glycine	H₂NCH₂COOH
Histidine	CH₂CH(NH₂)COOH
Proline
Serine	HOCH₂CH(NH₂)COOH

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthlate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.