Aminosyn HF 8
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Aminosyn HF 8%
AMINOSYN®-HF 8%
(amino acid) Injection
Flexible Plastic Container
Avoid exposure to light until use
Hepatic Formula
DRUG DESCRIPTION
Aminosyn-HF 8% (amino acid injection 8%) is a sterile, nonpyrogenic, hypertonic solution for intravenous infusion. The formulation is described below:
Aminosyn-HF 8% An Amino Acid Injection–Hepatic Formula Essential
Amino Acids (mg/100 mL)
| Isoleucine | 900 |
| Leucine | 1,100 |
| Lysine (acetate)* | 610 |
| Methionine | 100 |
| Phenylalanine | 100 |
| Threonine | 450 |
| Tryptophan | 66 |
| Valine | 840 |
| *Amount cited is for lysine alone and does not include the acetate salt. | |
Nonessential Amino Acids (mg/100 mL)
| Alanine | 770 |
| Arginine | 600 |
| Cysteine HCl • H20 | < 20 |
| Glycine | 900 |
| Histidine | 240 |
| Proline | 800 |
| Serine | 500 |
Electrolytes (mEq/Liter)
| Sodium (Na+) | 11 |
| Phosphate (HPO=4) | 20a |
| Acetate (C2H3O2-)b | approx. 62c |
| Chloride (Cl-) | < 3 |
| a 10 mmoles P/L b Including ions for pH adjustment c From lysine acetate |
|
Product Characteristics per 100 mL
| Nitrogen | 1.2gd |
| Sodium Hydrosulfite | 100mge |
| Phosphoric Acid | 115mg |
| pH | 6.4 |
| pH Range | 6.0 to 7.0f |
| Osmolarity | 768 mOsmol/Liter |
| Specific Gravity | 1.02 |
| d 7.6g of protein equivalent e Added as the antioxidant f Adjusted with glacial acetic acid |
|
The formulas for the individual amino acids present in Aminosyn–HF 8% are as follows:
Essential Amino Acids
| Isoleucine | CH3CH2CH(CH3)CH(NH2)COOH |
| Leucine | (CH3)2CHCH2CH(NH2)COOH |
| Lysine (acetate) | H2N(CH2)4CH(NH2)COOH • CH3COOH |
| Methionine | CH3S(CH2)2CH(NH2)COOH |
| Phenylalanine |  CH |
| Threonine | CH3CH(OH)CH(NH2)COOH |
| Tryptophan |  CH2CH(NH2)COOH |
| Valine | (CH3)2CHCH(NH2)COOH |
Nonessential Amino Acids
| Alanine | CH3CH(NH2)COOH |
| Arginine | H2NC(NH)NH(CH2)3CH(NH2)COOH |
| Cysteine HCl • H20 | HSCH2CH(NH2)COOH • HCl • H20 |
| Glycine | H2NCH2COOH |
| Histidine |  CH2CH(NH2)COOH |
| Proline |  |
| Serine | HOCH2CH(NH2)COOH |
The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.
Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthlate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.
Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Aminosyn HF 8% Information
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