May 22, 2017
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Aminosyn II 4.25

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Aminosyn II 4.25% in 25% Dextrose

in 25% Dextrose Injection

NOTE: These solutions are hypertonic. See WARNINGS and PRECAUTIONS.
Nutrimix® Dual-chamber Flexible Container
The Upper Chamber Contains 500 mL of Aminosyn II 8.5% (An Amino Acid Injection)
The Lower Chamber Contains 500 mL of 50% Dextrose Injection, USP


Upper Chamber: Aminosyn II 8.5%, an amino acid injection, 500 mL.

Aminosyn II 8.5% is a sterile, nonpyrogenic solution for intravenous infusion. The formulation is described in the table below.

Lower Chamber: 50% Dextrose Injection, USP, 500 mL.

50% Dextrose Injection, USP (concentrated dextrose in water) is a sterile, nonpyrogenic, hypertonic solution of Dextrose, USP in water for injection. The table below indicates the characteristics of this concentrated solution.

The container must be used only after removing the clamp and thoroughly mixing the contents of the two chambers. The solution resulting from mixing the contents of the upper and the lower chamber will be 4.25% amino acids in 25% dextrose. Mixing the contents of the upper and lower chambers yields a concentrated source of amino acids and carbohydrate calories for intravenous infusion. Headspace contains Nitrogen gas. The composition of this admixture is described in the table below.

  Solution Composition per 100 mL
Dextrose, hydrous (g)   50 25
Essential Amino Acids (mg)
  Isoleucine 561   280
  Leucine 850   425
  Lysine (as acetate salt)* 893   446
  Methionine 146   73
  Phenylalanine 253   126
  Threonine 340   170
  Tryptophan 170   85
  Valine 425   212
Nonessential Amino Acids (mg)
  Alanine 844   422
  Arginine 865   432
  L-Aspartic Acid 595   298
  L-Glutamic Acid 627   314
  Histidine 255   128
  Proline 614   307
  Serine 450   225
  N-Acetyl-L-Tyrosine 230   115
  Glycine 425   212
Total Amino Acids (g) 8.5   4.25
Protein Equivalent (g) 8.5   4.25
Total Nitrogen (g) 1.3   0.65
Electrolytes (mEq/liter)
  Sodiuma (Na+) 38   19
  Acetateb(C2H3O2–) 61.1   30.6
  Sodium hydrosulfite (mg/100 mL) 60   30
Osmolarity mOsmol/liter (actual) 780 1997 1522
pH 5.8 4.3 5.8
range 5.0 to 6.5c 3.2 to 6.5 5.0 to 6.5
*Amount cited is for lysine alone and does not include the acetate salt.
a Includes sodium from the pH adjustor sodium hydroxide and the antioxidant, sodium hydrosulfite.
b Includes acetate from lysine acetate.
c May contain sodium hydroxide for pH adjustment.

The formulas for the individual amino acids are as follows:

Essential Amino Acids
Isoleucine CH3CH2CH(CH3)CH(NH2)COOH
Leucine (CH3)2CHCH2CH(NH2)COOH
Lysine Acetate H2N(CH2)4CH(NH2)COOH • CH3COOH
Methionine CH3S(CH2)2CH(NH2)COOH
Phenylalanine structural formula illustration
Threonine CH3CH(OH)CH(NH2)COOH
Tryptophan structural formula illustration
Valine (CH3)2CHCH(NH2)COOH
Nonessential Amino Acids
Alanine CH3CH(NH2)COOH
Arginine H2NC(NH)NH(CH2)3CH(NH2)COOH
L-Aspartic Acid HOOCCH2CH(NH2)COOH
L-Glutamic Acid HOOC(CH2)2CH(NH2)COOH
Glycine H2NCH2COOH
Histidine structural formula illustration
Proline structural formula illustration
N-Acetyl-L-Tyrosine structural formula illustration
a Includes sodium from the pH adjustor sodium hydroxide and the antioxidant, sodium hydrosulfite.
b Includes acetate from lysine acetate.
c May contain sodium hydroxide for pH adjustment.

Dextrose, USP is chemically designated D-glucose, monohydrate (C6H12O6 •H2O), a hexose sugar freely soluble in water.

The flexible plastic container is fabricated from a specially formulated nonplasticized thermoplastic co-polyester (CR3). Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions inside the plastic container also can leach out certain of its chemical components in very small amounts before the expiration period is attained. However, the safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers.

Last reviewed on RxList: 11/22/2016
This monograph has been modified to include the generic and brand name in many instances.

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