Aminosyn II 5% in 25% Dextrose (Amino Acid Injection 5% in 25% Dextrose Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 24, 2012

Aminosyn II 5% in 25% Dextrose

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AMINOSYN® II 5%
in 25% Dextrose Injection

AN AMINO ACID INJECTION IN DEXTROSE INJECTION
NOTE: These solutions are hypertonic. See WARNINGS and PRECAUTIONS.
Nutrimix® Dual-chamber Flexible Container
The Upper Chamber Contains 500 mL of Aminosyn II 10% (An Amino Acid Injection)
The Lower Chamber Contains 500 mL of 50% Dextrose Injection, USP

DRUG DESCRIPTION

Upper Chamber: Contains 500 mL of Aminosyn II 10% (an amino acid injection) — a sterile, nonpyrogenic solution for intravenous infusion. The formulation is described in the table below.

Lower Chamber: Contains 500 mL of 50% Dextrose Injection, USP — a sterile, nonpyrogenic, hypertonic solution of Dextrose, USP in water for injection. The table below indicates the characteristics of this concentrated solution.

The container must be used only after removing the clamp and thoroughly mixing the contents of the two chambers. The solution resulting from mixing the contents of the upper and lower chamber contains 5% amino acids in 25% dextrose. Mixing the contents of the upper and lower chambers yields a concentrated source of amino acids and carbohydrate calories for intravenous infusion. Headspace contains Nitrogen gas. The composition of this admixture is described in the table below.

	Solution Composition per 100 mL
	Upper Chamber	Lower Chamber	Admixture
Dextrose, hydrous (g)		50	25
Essential Amino Acids (mg)
Isoleucine	660		330
Leucine	1000		500
Lysine (as acetate salt)*	1050		525
Methionine	172		86
Phenylalanine	298		149
Threonine	400		200
Tryptophan	200		100
Valine	500		250
Nonessential Amino Acids (mg)
Alanine	993		496
Arginine	1018		509
L-Aspartic Acid	700		350
L-Glutamic Acid	738		369
Glycine	500		250
Histidine	300		150
Proline	722		361
Serine	530		265
N-Acetyl-L-Tyrosine	270		135
Total Amino Acids (g)	10		5
Protein Equivalent (g)	10		5
Total Nitrogen (g)	1.53		0.77
Electrolytes (mEq/liter)
Sodium^a(Na+)	44.4		22.2
Acetate^b(C₂H₃O₂–)	71.8		35.9
Sodium hydrosulfite (mg/100 mL)	60		30
Osmolarity mOsmol/liter (actual)	868	1997	1539
pH	5.8	4.3	5.8
range^c	5.0 to 6.5	3.2 to 6.5	5.0 to 6.5
*Amount cited is for lysine alone and does not include the acetate salt. ^aIncludes sodium from the pH adjustor (sodium hydroxide) and the antioxidant, sodium hydrosulfite. ^bFrom lysine acetate. ^cContains sodium hydroxide for pH adjustment.

The formulas for the individual amino acids are as follows:

Essential Amino Acids
Isoleucine	CH₃CH₂CH(CH₃)CH(NH₂)COOH
Leucine	(CH₃)2CHCH₂CH(NH₂)COOH
Lysine Acetate	H₂N(CH₂)4CH(NH₂)COOH • CH₃COOH
Methionine	CH₃S(CH₂)2CH(NH₂)COOH
Phenylalanine	CH₂CH(NH₂)COOH
Threonine	CH₃CH(OH)CH(NH₂)COOH
Tryptophan	CH₂CH(NH₂)COOH
Valine	(CH₃)2CHCH(NH₂)COOH
Nonessential Amino Acids
Alanine	CH₃CH(NH₂)COOH
Arginine	H₂NC(NH)NH(CH₂)₃CH(NH₂)COOH
L-Aspartic Acid	HOOCCH₂CH(NH₂)COOH
L-Glutamic Acid	HOOC(CH₂)2CH(NH₂)COOH
Glycine	H₂NCH₂COOH
Histidine	CH₂CH(NH₂)COOH
Proline
Serine	HOCH₂CH(NH₂)COOH
N-Acetyl-L-Tyrosine

Dextrose, USP is chemically designated D-glucose, monohydrate (C₆H₁₂O₆ •H₂₀), a hexose sugar freely soluble in water.

The flexible plastic container is fabricated from a specially formulated nonplasticized thermoplastic co-polyester (CR3). Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions inside the plastic container also can leach out certain of its chemical components in very small amounts before the expiration period is attained. However, the safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers.

Last reviewed on RxList: 1/14/2009
This monograph has been modified to include the generic and brand name in many instances.