Aminosyn II 8.5% (Amino Acid Injection with Electrolytes) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Aminosyn II

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Aminosyn II 8.5%

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Aminosyn® II 8.5% WITH ELECTROLYTES
Sulfite-Free

AN AMINO ACID INJECTION WITH ELECTROLYTES
Flexible Plastic Container

DRUG DESCRIPTION

Aminosyn® II 8.5% WITH ELECTROLYTES, Sulfite-Free, (an amino acid injection with electrolytes) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn II 8.5% (amino acid injection with electrolytes) WITH ELECTROLYTES is oxygen sensitive. The following formulation is available:

Essential Amino Acids (mg/100 mL)

Isoleucine	561
Leucine	850
Lysine (acetate)*	893
Methionine	146
Phenylalanine	253
Threonine	340
Tryptophan	170
Valine	425
*Amount cited is for lysine alone and does not include the acetate salt.

Nonessential Amino Acids (mg/100 mL)

Alanine	844
Arginine	865
L-Aspartic Acid	595
L-Glutamic Acid	627
Histidine	255
Proline	614
Serine	450
N-Acetyl-L-Tyrosine	230
Glycine	425

Product Characteristics

Protein Equivalent (approx. g/liter)	85
Total Nitrogen (g/liter)	13.0
Osmolarity (mOsmol/L)	920
pH^a	5.8
range	5.0 - 6.5
^aContains sodium hydroxide for pH adjustment.

Electrolytes (mEq/liter)

Sodium (Na⁺)^b	78
Potassium (K⁺)	66
Magnesium (Mg⁺⁺)	10
Phosphorus mM^c	30
Chloride (CI^-)	86
Acetate (C₂H₃O₂-)	61^d
^b Includes sodium from the pH adjustor. ^c mM = millimoles; one mM of phosphorus = 31 mg P. ^d Includes acetate from lysine acetate.

Electrolytes (mg/100 mL)

Sodium Chloride^e	60 mg
Magnesium Chloride hexahydrate^f	102 mg
Sodium Phosphate, dibasic^g	425 mg
Potassium Chloride^h	492 mg
^e Sodium Chloride, USP is chemically designated NaCI, a white crystalline powder freely soluble in water. ^f Magnesium Chloride, USP is chemically designated magnesium chloride, hexahydrate, MgCl₂•6H₂O, deliquescent crystals very soluble in water. ^g Sodium Phosphate, dibasic, USP is chemically designated Na₂HPO₄, white granules very soluble in water. ^h Potassium Chloride, USP is chemically designated KCl, a white granular powder freely soluble in water.

The formulas for the individual amino acids present in Aminosyn II 8.5% (amino acid injection with electrolytes) WITH ELECTROLYTES are as follows:

Essential Amino Acids

Isoleucine, USP	C₆H₁₃NO₂
Leucine, USP	C₆H₁₃NO₂
Lysine Acetate, USP	C₆H₁₄N₂O₂ • CH₃COOH
Methionine, USP	C₅H₁₁NO₂S
Phenylalanine, USP	C₉H₁₁NO₂
Threonine, USP	C₄H₉NO₃
Tryptophan, USP	C₁₁H₁₂N₂O₂
Valine, USP	C₅H₁₁NO₂

Nonessential Amino Acids

Alanine, USP	C₃H₇NO₂
Arginine, USP	C₆H₁₄N₄O₂
L-Aspartic Acid	C₄H₇NO₄ HO₂CCH₂CH(NH₂)CO₂H
L-Glutamic Acid	C₅H₉NO₄ HO₂CCH₂CH₂CH(NH₂)CO₂H
Glycine, USP	C₂H₅NO₂
Histidine, USP	C₆H₉N₃O₂
Proline, USP	C₅H₉NO₂
Serine, USP	C₃H₇NO₃
N-Acetyl-L-Tyrosine	C₁₁H₁₃NO₄

N-Acetyl-L-Tyrosine structural formula illustration

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.