|
|
Aminosyn® II
in Dextrose Injection
AN AMINO ACID INJECTION IN DEXTROSE INJECTION
NOTE: These solutions are hypertonic. See WARNINGS
and PRECAUTIONS.
Nutrimix® Dual-chamber Flexible Container
The Upper Chamber Contains Aminosyn II (An Amino Acid Injection)
The Lower Chamber Contains Dextrose Injection, USP
Upper Chamber: Aminosyn II.
Aminosyn II (an amino acid injection) is a sterile, nonpyrogenic solution for intravenous infusion.
Lower Chamber: Dextrose Injection, USP.
Dextrose Injection, USP (concentrated dextrose in water) is a sterile, nonpyrogenic, hypertonic solution of Dextrose, USP in water for injection.
The container must be used only after opening the clamp and thoroughly mixing the contents of the two chambers. Mixing the contents of the upper and lower chamber yields a concentrated source of amino acids and carbohydrate calories for intravenous infusion. Headspace contains Nitrogen gas. The composition of these admixtures is described in the table below.
SOLUTION COMPOSITION BEFORE COMBINATION
| UPPER CHAMBER (500 mL) | Amino Acid Concentrations 8.5% |
| Essential Amino Acids (mg/100 mL) | |
| Isoleucine | 561 |
| Leucine | 850 |
| Lysine (as acetate salt)* | 893 |
| Methionine | 146 |
| Phenylalanine | 253 |
| Threonine | 340 |
| Tryptophan | 170 |
| Valine | 425 |
| Amino Acid Concentrations 8.5% | |
| Nonessential Amino Acids (mg/100 mL) | |
| Alanine | 844 |
| Arginine | 865 |
| L-Aspartic Acid | 595 |
| L-Glutamic Acid | 627 |
| Glycine | 425 |
| Histidine | 255 |
| Proline | 614 |
| Serine | 450 |
| N-Acetyl-L-Tyrosine | 230 |
| Amino Acid Concentrations 8.5% | |
| Electrolytes (mEq/L) | |
| Sodiuma(Na+) | 38 |
| Acetateb(C2H3O2–) | 61.1 |
| Sodium Hydrosulfite (Na2S2O4) added (mg/100 mL) | 60 |
| Other Characteristics | |
| Osmolarity (actual mOsmol/L) | 780 |
| pHc | 5.8 |
| (range) | 5.0 – 6.5 |
| Total Amino Acids (g/L) | 85 |
| Protein Equivalent (g/L) | 85 |
| Total Nitrogen (g/L) | 13.0 |
| *Amount cited is for lysine alone and does
not include acetate salt. a From the antioxidant, sodium hydrosulfite, and from the pH adjustor, sodium hydroxide. b From lysine acetate. c May contain sodium hydroxide for pH adjustment. |
|
SOLUTION COMPOSITION BEFORE COMBINATION
| LOWER CHAMBER (500 mL) | ||
| Dextrose Injection, USP | 20% | 40% |
| Dextrose, hydrous (g/100 mL) | 20 | 40 |
| Energy (kcal/100 mL) | 68 | 136 |
| Osmolarity (actual mOsmol/L) | 934 | 1740 |
| pH | 4.1 | 4.2 |
| (range) | 3.2 – 6.5 | 3.2 – 6.5 |
SOLUTION COMPOSITION AFTER COMBINATION (1000 mL)
| Amino Acid Concentrations 4.25% |
||
| Essential Amino Acids (mg/100 mL) | ||
| Isoleucine | 280 | |
| Leucine | 425 | |
| Lysine (as acetate salt)* | 446 | |
| Methionine | 73 | |
| Phenylalanine | 126 | |
| Threonine | 170 | |
| Tryptophan | 85 | |
| Valine | 212 | |
| Nonessential Amino Acids (mg/100 mL) | ||
| Alanine | 422 | |
| Arginine | 432 | |
| L-Aspartic Acid | 298 | |
| L-Glutamic Acid | 314 | |
| Glycine | 212 | |
| Histidine | 128 | |
| Proline | 307 | |
| Serine | 225 | |
| N-Acetyl-L-Tyrosine | 115 | |
| Electrolytes (mEq/L) | ||
| Aminosyn II (%)/Dextrose (%) | 4.25/20 | 4.25/10 |
| Sodiuma (Na+) | 19 | 19 |
| Acetateb (C2H3O2-) | 30.6 | 30.6 |
| Sodium Hydrosulfite (Na2S2O4) added (mg/100 mL) | 30 | 30 |
| Other Characteristics | ||
| Dextrose, hydrous (g/100 mL) | 20 | 10 |
| Osmolarity (actual mOsmol/L) | 1295 | 894 |
| pHc | 5.8 | 5.8 |
| (range) | 5.0 – 6.5 | 5.0 – 6.5 |
| Total Amino Acids (g/L) | 42.5 | 42.5 |
| Protein Equivalent (g/L) | 42.5 | 42.5 |
| Total Nitrogen (g/L) | 6.5 | 6.5 |
| *Amount cited is for lysine alone and does
not include acetate salt. a From the antioxidant, sodium hydrosulfite, and from the pH adjustor, sodium hydroxide. b From lysine acetate. c May contain sodium hydroxide for pH adjustment. |
||
The formulas for the individual amino acids present are as follows:
| Essential Amino Acids | |
| Isoleucine | CH3CH2CH(CH3)CH(NH2)COOH |
| Leucine | (CH3)2CHCH2CH(NH2)COOH |
| Lysine Acetate | H2N(CH2)4CH(NH2)COOH • CH3COOH |
| Methionine | CH3S(CH2)2CH(NH2)COOH |
| Phenylalanine |
 CH2CH(NH2)COOH |
| Threonine | CH3CH(OH)CH(NH2)COOH |
| Tryptophan |
 CH2CH(NH2)COOH |
| Valine | (CH3)2CHCH(NH2)COOH |
| Nonessential Amino Acids | |
| Alanine | CH3CH(NH2)C H |
| Arginine | H2NC(NH)NH(CH2)3CH(NH2)C H |
| L-Aspartic Acid | HOOCCH2CH(NH2)COOH |
| L-Glutamic Acid | HOOC(CH2)2CH(NH2)COOH |
| Glycine | H2NCH2COOH |
| Histidine |
 CH2CH(NH2)COOH |
| Proline |
|
| Serine | HOCH2CH(NH2)COOH |
| N-Acetyl-L-Tyrosine |
|
Dextrose, USP is chemically designated D-glucose, monohydrate (C6H12O6• H2O), a hexose sugar freely soluble in water.
 |
The flexible plastic container is fabricated from a specially formulated nonplasticized thermoplastic co-polyester (CR3). Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions inside the plastic container also can leach out certain of its chemical components in very small amounts before the expiration period is attained. However, the safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers.
Last reviewed on RxList: 1/14/2009
This monograph has been modified to include the generic and brand name in many instances.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips, recipes and inspiration.
Copyright © 2012 by WebMD, LLC.
RxList does not provide medical advice, diagnosis or treatment. See additional information.
Updated & New