Aminosyn II Injection (Amino Acid Injection) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 24, 2012

Aminosyn II Injection

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Aminosyn® II
(an amino acid) Injection

Pharmacy Bulk Package—Not For Direct Infusion.
Flexible Plastic Container

DRUG DESCRIPTION

Aminosyn® II (an amino acid injection) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn II is oxygen sensitive. The Pharmacy Bulk Package is a sterile dosage form which contains multiple single doses for use only in a pharmacy bulk admixture program. The formulations are described

Essential Amino Acids (mg/100 mL)	Aminosyn II
Essential Amino Acids (mg/100 mL)	10%	15%
Isoleucine	660	990
Leucine	1000	1500
Lysine (acetate)*	1050	1575
Methionine	172	258
Phenylalanine	298	447
Threonine	400	600
Tryptophan	200	300
Valine	500	750
*Amount cited is for lysine alone and does not include the acetate.
Nonessential Amino Acids (mg/100 mL)
Alanine	993	1490
Arginine	1018	1527
L-Aspartic Acid	700	1050
L-Glutamic Acid	738	1107
Histidine	300	450
Proline	722	1083
Serine	530	795
N-Acetyl-L-Tyrosine	270	405
Glycine	500	750
Other Characteristics
Protein Equivalent (approx. grams/liter)	100	150
Total Nitrogen (grams/liter)	15.3	23.0
Osmolarity (mOsmol/liter, actual)	870	1300
pH^a	5.8 (5.0 –6.5)	5.8 (5.0 –6.5)
Specific Gravity	1.03	1.05
Electrolytes (mEq/L)
Sodium (Na+)^b	39.8	58.1
Acetate (C2H3O2–)^c	71.8	107.6
Sodium Hydrosulfite(mg/100mL)	20	20
^a Solution contains sodium hydroxide for pH adjustment. ^b Figure includes Na+ from the antioxidant, sodium hydrosulfite and from the pH adjustor. ^c Includes acetate from lysine acetate.

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts to affect the solution significantly.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

The formulas for the individual amino acids are as follows:

Essential Amino Acids
Isoleucine	CH₃CH₂CH(CH₃)CH(NH₂)COOH
Leucine	(CH₃)₂CHCH₂CH(NH₂)COOH
Lysine Acetate	H₂N(CH₂)4CH(NH₂)COOH • CH₃COOH
Methionine	CH₃S(CH₂)₂CH(NH₂)COOH
Phenylalanine	CH₂CH(NH₂)COOH
Threonine	CH₃CH(OH)CH(NH₂)COOH
Tryptophan	CH₂CH(NH₂)COOH
Valine	(CH₃)₂CHCH(NH₂)COOH
Nonessential Amino Acids
Alanine	CH₃CH(NH₂)COOH
Arginine	H₂NC(NH)NH(CH2)₃CH(NH₂)COOH
L-Aspartic Acid	HOOCCH₂CH(NH₂)COOH
L-Glutamic Acid	HOOC(CH₂)₂CH(NH₂)COOH
Glycine	H₂NCH₂COOH
Histidine	CH₂CH(NH₂)COOH
Proline
Serine	HOCH₂CH(NH₂)COOH
N-Acetyl-L-Tyrosine

The Pharmacy Bulk Package is designed for use with manual, gravity flow operations and automated compounding devices for preparing sterile parenteral nutrient admixtures; it contains no bacteriostat. Multiple single doses may be dispensed during continual aliquoting operations. Withdrawal of container contents should be promptly completed within 4 hours after initial closure puncture.

Last reviewed on RxList: 1/14/2009
This monograph has been modified to include the generic and brand name in many instances.