Aminosyn PF 10
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Aminosyn PF 10% Sulfite Free
Aminosyn® -PF 10% (amino acid injection 10% pediatric formula)
AN AMINO ACID INJECTION - PEDIATRIC FORMULA
Pharmacy Bulk Package – Not for Direct Infusion.
Flexible Plastic Container
Aminosyn®-PF 10%, Sulfite-Free, (an amino acid injection — pediatric formula) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn-PF 10% is oxygen sensitive. The Pharmacy Bulk Package is a sterile dosage form which contains multiple single doses for use only in a pharmacy bulk admixture program. The formulation is described below:
An Amino Acid Injection — Pediatric Formula
Essential Amino Acids (mg/100 mL)
|*Amount cited is for lysine alone and does not include the acetate salt.|
|Nonessential Amino Acids (mg/100 mL)|
|Acetate (C2H3O2–) a||46|
|Protein Equivalent (Approx. grams/L)||100|
|Total Nitrogen (grams/L)||15.2|
|pH (range)||5.5 (5.0 to 6.5)|
|a From lysine acetate.|
The formulas for the individual amino acids present in Aminosyn-PF 10% are as follows:
Essential Amino Acids
|Lysine Acetate||H2N(CH2)4CH(NH2)COOH • CH3COOH|
Nonessential Amino Acids
|Taurine||H2N – CH2CH2 – SO3H|
The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.
Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.
Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
The Pharmacy Bulk Package is designed for use with manual, gravity flow operations and automated compounding devices for preparing sterile parenteral nutrient admixtures; it contains no bacteriostat. Multiple single doses may be dispensed during continual aliquoting operations. Withdrawal of container contents should be promptly completed within 4 hours after initial closure puncture.
Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Aminosyn PF 10% Sulfite Free Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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