Aminosyn PF 7% Sulfite Free (Amino Acid Injection 7% Pediatric Formula) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 24, 2012

Aminosyn PF 7% Sulfite Free

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Aminosyn® -PF 7% (amino acid injection 7% pediatric formula)
Sulfite-Free

AN AMINO ACID INJECTION - PEDIATRIC FORMULA
Flexible Plastic Container

DRUG DESCRIPTION

Aminosyn®-PF 7%, Sulfite-Free, (an amino acid injection — pediatric formula) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn®-PF 7% is oxygen sensitive. The formulation is described below:

Aminosyn-PF 7%
An Amino Acid Injection — Pediatric Formula
Essential Amino Acids (mg/100 mL)

Isoleucine	534
Leucine	831
Lysine (acetate)*	475
Methionine	125
Phenylalanine	300
Threonine	360
Tryptophan	125
Valine	452
* Amount cited is for lysine alone and does not include the acetate salt.

Nonessential Amino Acids (mg/100 mL)

Alanine	490
Arginine	861
L-Aspartic Acid	370
L-Glutamic Acid	576
Glycine	270
Histidine	220
Proline	570
Serine	347
Taurine	50
Tyrosine	44

Electrolytes (mEq/L)

Sodium (Na⁺) (mEq/L)	None
Potassium (K⁺) (mEq/L)	None
Chloride (Cl^–) (mEq/L)	None
Acetate (C₂H₃O₂–)^a (mEq/L)	32.5
^a From lysine acetate.

Product Characteristics

Protein Equivalent (Approx. grams/L)	70
Total Nitrogen (grams/L)	10.69
Osmolarity (mOsmol/L)	561
pH (range)	5.5 (5.0 to 6.5)

The formulas for the individual amino acids present in Aminosyn-PF 7% are as follows:

Essential Amino Acids

Isoleucine, USP	C₆H₁₃NO₂
Leucine, USP	C₆H₁₃NO₂
Lysine Acetate, USP	C₆H₁₄N₂O₂ • CH₃COOH
Methionine, USP	C₅H₁₁NO₂S
Phenylalanine, USP	C₉H₁₁NO₂
Threonine, USP	C₄H₉NO₃
Tryptophan, USP	C₁₁H₁₂N₂O₂
Valine, USP	C₅H₁₁NO₂

Nonessential Amino Acids

Alanine, USP	C₃H₇NO₂
Glycine, USP	C₂H₅NO₂
Arginine, USP	C₆H₁₄N₄O₂
L-Aspartic Acid	C₄H₇NO₄ HO₂CCH₂CH(NH₂)CO₂H
L-Glutamic Acid	C₅H₉NO₄ HO₂CCH₂CHCH(NH₂)CO₂H
Histidine, USP	C₆H₉N₃O₂
Proline, USP	C₅H₉NO₂
Serine, USP	C₃H₇NO₃
Taurine	C₂H₇NO₃S
Tyrosine, USP	C₉H₁₁NO₃

The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.

Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.

Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.