Aminosyn RF 5.2
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Aminosyn RF 5.2% Sulfite Free
Aminosyn®-RF 5.2%
Sulfite-Free
AN AMINO ACID INJECTION — RENAL FORMULA
Flexible Plastic Container
DRUG DESCRIPTION
Aminosyn®-RF 5.2%, Sulfite-Free, (an amino acid injection — renal formula) is a sterile, nonpyrogenic solution for intravenous infusion. Aminosyn-RF 5.2% is oxygen sensitive. The solution contains the following crystalline amino acids:
| mg/100 mL | Min. Daily Need (mg**) |
|
| Essential Amino Acids | ||
| Isoleucine | 462 | 700 |
| Leucine | 726 | 1100 |
| Lysine Acetate* | 535 | 800 |
| Methionine | 726 | 1100 |
| Phenylalanine | 726 | 1100 |
| Threonine | 330 | 500 |
| Tryptophan | 165 | 250 |
| Valine | 528 | 800 |
| Nonessential Amino Acids | ||
| Arginine | 600 | __ |
| Histidine*** | 429 | __ |
| * Amount cited is for Lysine alone and does not include the
acetate salt. ** The minimum daily quantities needed to maintain nitrogen balance in the healthy adult. (Rose, W.C., The Sequence of Events Leading to the Establishment of the Amino Acid Needs of Man, Am J. Public Health, 58:2020, 1968.) *** Histidine is considered essential for patients in renal failure. |
||
Electrolytes and Product Characteristics
| Acetate (C2H3O2_)a (mEq/Liter) | 113 |
| Protein Equivalent (approx. grams/liter) | 52.27 |
| Total Nitrogen (grams/liter) | 7.93 |
| Osmolarity (mOsmol/liter) | 427 |
| pH (Range) | 5.2 (4.5 to 6.0b) |
| a Includes acetate from acetic acid used in processing
and from Lysine acetate. b Adjusted with acetic acid. |
|
Each 500 mL represents three Rose Units of essential amino acids plus arginine and histidine. The formulas for the individual amino acids present in Aminosyn-RF 5.2% are as follows:
| Essential Amino Acids | |
| Isoleucine, USP | (C6H13NO2) |
| Leucine, USP | (C6H13NO2) |
| Lysine Acetate, USP | (C6H14N2O2•CH3COOH) |
| Methionine, USP | (C5H11NO2S) |
| Phenylalanine, USP | (C9H11NO2) |
| Threonine, USP | (C4H9NO3) |
| Tryptophan, USP | (C11H12N2O2) |
| Valine, USP | (C5H11NO2) |
| Nonessential Amino Acids | |
| Arginine, USP | (C6H14N4O2) |
| Histidine, USP | (C6H9N3O2) |
The flexible plastic container is fabricated from a specially formulated polyvinylchloride. Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly.
Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials.
Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.
Last reviewed on RxList: 1/13/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Aminosyn RF 5.2% Sulfite Free Information
Report Problems to the Food and Drug Administration
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