Atrial fibrillation (AF) is the most common, abnormal rhythm of the heart.
The heart contracts (beats) and pumps blood with a regular rhythm, for example,
at a rate of 60 beats per minute there is a beat every second. The heart may
beat faster or slower with a shorter or longer interval between beats, but at
any one rate the interval between beats is constant. This regular rhythm occurs
as a result of regular electrical discharges (currents) that travel through the
heart and cause the muscle of the heart to contract. In atrial fibrillation, the electrical
discharges are irregular and rapid and, as a result, the heart beats irregularly
and, usually, rapidly.
Atrial fibrillation is common; half a million new cases are diagnosed yearly
in the U.S., and billions of dollars are spent annually on its diagnosis and
treatment.
Normal function of the he...
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Amiodarone HCl Injection
For Intravenous Use Only
Amiodarone HCl Injection contains amiodarone HCl (C25H29I2NO3•HCl), a class III antiarrhythmic drug. Amiodarone HCl is (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride. Amiodarone HCl has the following structural formula:
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Amiodarone HCl is a white to slightly yellow crystalline powder, and is very slightly soluble in water. It has a molecular weight of 681.78 and contains 37.3% iodine by weight. Amiodarone HCl injection is a sterile clear, pale-yellow micellar solution visually free from particulates. Each milliliter of the amiodarone HCl injection formulation contains 50 mg of amiodarone HCl, 20.2 mg of benzyl alcohol NF, 100 mg of polysorbate 80 NF, and Water for Injection USP.
Last reviewed on RxList: 11/18/2008
This monograph has been modified to include the generic and brand name in many instances.
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