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Amitiza Patient Information including How Should I Take

What should I discuss with my health care provider before taking lubiprostone (Amitiza)?

You should not use this medication if you have a blockage in your digestive tract, or if you have severe diarrhea.

To make sure lubiprostone is safe for you, tell your doctor if you have any other cause for obstruction in your gastrointestinal (digestive) system, such as:

  • gallstones;
  • Crohn's disease;
  • Hirschsprung's disease;
  • impacted bowel movement;
  • diverticulitis, polyps; or
  • a history of hernia.

Also tell your doctor if you have liver disease.

FDA pregnancy category C. It is not known whether lubiprostone will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether lubiprostone passes into breast milk or if it could harm a nursing baby. However, a nursing baby could develop diarrhea if the mother takes lubiprostone while breast-feeding. Tell your doctor if you are breast-feeding a baby, and talk with your doctor if the baby develops diarrhea.

Lubiprostone should not be given to a child.

How should I take lubiprostone (Amitiza)?

Lubiprostone is usually taken twice daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take lubiprostone with food or milk.

Drink a full glass of water when you take this medication.

You may have tightness in your chest or feel short of breath within 1 hour after taking lubiprostone. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions.

Store at room temperature away from moisture and heat.

Side Effects Centers

Amitiza - User Reviews

Amitiza User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Amitiza sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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