Amoxil (Amoxicillin) Drug Information: Overdosage and Contraindications

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May 24, 2012

Amoxicillin

Sore Throat (Pharyngitis) »

Sore throat facts

Most sore throats are caused by viruses or mechanical causes (such as mouth breathing) and can be treated successfully at home.
Sore throat symptoms include pain, burning or scratching sensations at the back of the throat, pain when swallowing, and tenderness in the neck. Sore throat symptoms may be accompanied by coughing, sneezing, fever, and swollen lymph nodes.
Home remedies for sore throat include saltwater gargles, sprays, lozenges and humidifiers. Do not give lozenges to young children as they are a choking hazard.
Any sore throat that has a rapid onset and is associated with a fever or tenderness of the front of the neck may be serious and should be seen by a doctor.
Any sore throat that causes a person to have difficulty swallowing (not just pain with swallowing) or breathing should be seen by a health care ...

Read the Sore Throat (Pharyngitis) article »

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OVERDOSE

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of amoxicillin are not associated with significant clinical symptoms. Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with amoxicillin¹.

Crystalluria, in some cases leading to renal failure, has also been reported after amoxicillin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of amoxicillin crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of amoxicillin. Amoxicillin may be removed from circulation by hemodialysis.

CONTRAINDICATIONS

AMOXIL is contraindicated in patients who have experienced a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other β-lactam antibiotics (e.g., penicillins and cephalosporins).

REFERENCES

1. Swanson-Biearman B, Dean BS, Lopez G, Krenzelok EP. The effects of penicillin and cephalosporin ingestions in children less than six years of age. Vet Hum Toxicol. 1988; 30: 66-67.

Last reviewed on RxList: 12/6/2011
This monograph has been modified to include the generic and brand name in many instances.