Amphadase (Hyaluronidase Inj) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 10, 2012

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Amphadase

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Amphadase™
(hyaluronidase) Injection, USP

DRUG DESCRIPTION

Amphadase (hyaluronidase inj) is a preparation of purified bovine testicular hyaluronidase, a protein enzyme. The exact chemical structure of this enzyme is unknown. However, the amino acid sequence for the primary structure of the enzyme has been deduced from the sequence of purified peptides.

Amphadase (hyaluronidase injection) is supplied as a sterile, colorless, ready for use solution. Each vial contains 150 USP units of hyaluronidase per mL with 8.5 mg sodium chloride, 1 mg edetate disodium, 0.4 mg calcium chloride, monobasic sodium phosphate buffer, and not more than 0.1 mg thimerosal (mercury derivative).

The ready for use solution is clear and colorless with an approximate pH of 6.8 and an osmolality of 295 to 355 mOsm.

What are the possible side effects of hyaluronidase (Amphadase, Hydase, Hylenex, Vitrase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

pain or tenderness where the medication was injected; or
swelling in any part of your body.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Amphadase »

Last reviewed on RxList: 1/29/2009
This monograph has been modified to include the generic and brand name in many instances.