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Brand Names: Amphadase, Hydase, Hylenex, Vitrase

Generic Name: hyaluronidase (injectable) (Pronunciation: HYE al ure ON i dase)

• What is hyaluronidase (Amphadase)?
• What are the possible side effects of hyaluronidase (Amphadase)?
• What is the most important information I should know about hyaluronidase (Amphadase)?
• What should I discuss with my health care provider before receiving hyaluronidase (Amphadase)?
• How should I use hyaluronidase (Amphadase)?
• What happens if I miss a dose (Amphadase)?
• What happens if I overdose (Amphadase)?
• What should I avoid while receiving hyaluronidase (Amphadase)?
• What other drugs will affect hyaluronidase (Amphadase)?
• Where can I get more information?

What is hyaluronidase (Amphadase)?

Hyaluronidase is a genetically designed protein.

Hyaluronidase is used as an aid in helping your body absorb other injected medications.

Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Hyaluronidase may also be used for other purposes not listed in this medication guide.

What are the possible side effects of hyaluronidase (Amphadase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

• pain or tenderness where the medication was injected; or
• swelling in any part of your body.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hyaluronidase (Amphadase)?

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Before receiving hyaluronidase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).