May 29, 2017
Recommended Topic Related To:


"Repeated subcutaneous injections of botulinum toxin A (Botox, Allergan) provides analgesic relief to patients with neuropathic pain, a new randomized controlled trial has shown.

The study showed that two series of injections "...




(cyclobenzaprine hydrochloride) Extended-release Capsules

Read this Patient Information before you start taking AMRIX and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is AMRIX?

AMRIX is a prescription medicine used along with rest and physical therapy to help treat muscle spasm due to acute, painful musculoskeletal problems.

AMRIX should only be used for up to 2 or 3 weeks. It is not known if AMRIX is effective when used for longer periods.

It is not known if AMRIX is safe and effective in children.

Who should not take AMRIX?

Do not take AMRIX if you:

  • are allergic to cyclobenzaprine or any of the ingredients in AMRIX. See the end of this Patient Information leaflet for a complete list of ingredients in AMRIX.
    Talk to your healthcare provider or get medical help right away if you have symptoms of an allergic reaction such as:
    • difficulty breathing
    • hives
    • swelling of your face or tongue
    • itching
  • are taking certain antidepressants, known as monoamine oxidase (MAO) inhibitors or it has been 14 days or less since you stopped taking a MAO inhibitor. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.
  • have had a recent heart attack
  • have heart rhythm problems (arrhythmias)
  • have heart failure
  • have an overactive thyroid (hyperthyroidism)

Talk to your healthcare provider before taking this medicine if you have any of the conditions listed above.

What should I tell my healthcare provider before taking AMRIX?

Before you take AMRIX, tell your healthcare provider if you:

  • have a history of eye problems including glaucoma
  • have heart problems or have had a heart attack
  • have liver problems
  • have trouble emptying your bladder (urinary retention)
  • are pregnant or plan to become pregnant. It is not known if AMRIX will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if AMRIX passes into your breast milk. You and your healthcare provider should decide if you will take AMRIX or breastfeed.

AMRIX may affect the way other medicines work, and other medicines may affect how AMRIX works.

Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take:

  • a medicine to treat depression, mood, anxiety, psychotic or thought disorders
  • a pain medicine called tramadol or meperidine
  • barbiturates or other medicines that depress your central nervous system (CNS depressants)
  • a medicine that prevents nerve impulses (anticholinergic medicines)
  • a medicine to help quit smoking called bupropion
  • a blood pressure medicine called verapamil

Ask your doctor or pharmacist if you are not sure if you take any of the medicines listed above.

Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider or pharmacist when you get a new medicine.

How should I take AMRIX?

  • Take AMRIX exactly as your healthcare provider tells you to take it.
  • Your healthcare provider will tell you how much AMRIX to take and when to take it.
  • Your healthcare provider may change your AMRIX dose if needed.
  • Take AMRIX around the same time every day.
  • AMRIX should only be taken for short periods (up to two or three weeks).
  • If you take too much AMRIX, call your doctor or go to the nearest hospital emergency room right away.

What should I avoid while taking AMRIX?

You should not drink alcohol until you know how AMRIX affects you. Taking AMRIX with alcohol or other medicines that depress your central nervous system can slow your thinking and physical response times.

Do not drive, operate machinery, or do other dangerous activities until you know how AMRIX affects you.

What are the possible side effects of AMRIX?

AMRIX may cause serious side effects that may lead to heart attack or stroke. Call your healthcare provider right away or go to the nearest hospital emergency room if you have:

  • irregular or abnormal heartbeats (arrhythmias)
  • fast heartbeat (tachycardia)

Serotonin syndrome is a serious medical condition that may happen when AMRIX is taken with certain other medicines. Call your healthcare provider right away or go to the nearest hospital emergency room if you become severely ill and have some or all of these symptoms:

  • agitation, hallucinations, coma or other changes in mental status
  • coordination problems or muscle twitching (overactive reflexes)
  • fast heartbeat, high or low blood pressure
  • sweating or fever
  • nausea, vomiting, or diarrhea
  • muscle stiffness or tightness

The most common side effects of AMRIX include:

  • dry mouth
  • dizziness
  • fatigue
  • constipation
  • nausea
  • upset stomach
  • drowsiness

Tell your healthcare provider if you get any side effect that bothers you or that does not go away.

These are not all the possible side effects of AMRIX. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.

How should I store AMRIX?

  • Store AMRIX at room temperature, between 59° F to 86°F (15°C to 30°C).
  • Keep AMRIX in a tightly closed container, and keep AMRIX out of light.
  • Keep AMRIX and all medicines out of the reach of children.

General information about the safe and effective use of AMRIX.

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use AMRIX for a condition for which it was not prescribed. Do not give AMRIX to other people, even if they have the same symptoms you have. It may harm them.

This Patient Information leaflet summarizes the most important information about AMRIX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about AMRIX that is written for healthcare professionals.

For more information, go to or call 1-800-896-5855.

What are the ingredients in AMRIX?

Active Ingredient: cyclobenzaprine hydrochloride USP

Inactive Ingredients: diethyl phthalate NF, ethylcellulose NF (Ethocel Standard 10 Premium), gelatin, Opadry® Clear YS-1-7006, sugar spheres NF (20-25 mesh), and titanium dioxide.

AMRIX 15 mg capsules also contain: D&C yellow #10, FD&C green #3, and FD&C red #40.

AMRIX 30 mg capsules also contain: FD&C blue #1, FD&C blue #2, FD&C red #40, and FD&C yellow #6.

Last reviewed on RxList: 2/12/2016
This monograph has been modified to include the generic and brand name in many instances.

Amrix - User Reviews

Amrix User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Amrix sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Chronic Pain/Back Pain

Find tips and advances in treatment.

Related Drugs
Health Resources
Use Pill Finder Find it Now See Interactions

Pill Identifier on RxList

  • quick, easy,
    pill identification

Find a Local Pharmacy

  • including 24 hour, pharmacies

Interaction Checker

  • Check potential drug interactions
Search the Medical Dictionary for Health Definitions & Medical Abbreviations