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Amytal Sodium

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Amytal Sodium

(amobarbital sodium) for Injection, USP

CAUTION: These products are to be used under the direction of a physician

The intravenous administration of Amytal® Sodium (Amobarbital Sodium for Injection, USP) carries with it the potential dangers inherent in the intravenous use of any potent hypnotic.


The barbiturates are nonselective central nervous system (CNS) depressants that are primarily used as sedative hypnotics. In subhypnotic doses, they are also used as anticonvulsants. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act.

Amobarbital sodium is a white, friable, granular powder that is odorless, has a bitter taste, and is hygroscopic. It is very soluble in water soluble in alcohol, and practically insoluble in ether and chloroform. Amobarbital sodium is sodium 5-ethyl-5-isopentylbarbiturate and has the empirical formula C11H17N2Na03. Its molecular weight is 248.26. It has the following structural formula:

AMYTAL® SODIUM (Amobarbital sodium) structural formula illustration

Amobarbital sodium is a substituted pyrimidine derivative in which the basic structure is barbituric acid, a substance that has no CNS activity.

Vials of amobarbital sodium are for parenteral administration. The vials contain 500 mg (2 mmol) amobarbital sodium as a sterile lyophilized powder.

Last reviewed on RxList: 8/21/2009
This monograph has been modified to include the generic and brand name in many instances.

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