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Adrenalin Chloride Solution
(Epinephrine Injection, USP), 1:1000


A sterile solution intended for subcutaneous or intramuscular injection. When diluted, it may also be administered intracardially or intravenously. Each milliliter contains 1 mg Adrenalin (epinephrine) as the hydrochloride dissolved in Water for Injection, USP, with sodium chloride added for isotonicity. The ampoules contain not more than 0.1% sodium bisulfite as an antioxidant, and the air in the ampoule has been displaced by nitrogen. The Steri-Vials® contain 0.5% Chlorobutanol (chloroform derivative) as a preservative and not more than 0.15% sodium bisulfite as an antioxidant. Epinephrine is the active principle of the adrenal medulla, chemically described as (—)-3,4-Dihydroxy-α-[(methylamino) methyl] benzyl alcohol, and has the following structural formula:

Epinephrine  structural formula illustration

Last reviewed on RxList: 12/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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