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Fatalities may also result from pulmonary edema because of the peripheral constriction and cardiac stimulation produced. Rapidly acting vasodilators, such as nitrites, or alpha blocking agents may counteract the marked pressor effects of epinephrine.
Epinephrine is the preferred treatment for serious allergic or other emergency situations even though this product contains sodium bisulfite, a sulfite that may in other products cause allergic-type reactions including anaphylactic symptoms or life-threatening or less severe asthmatic episodes in certain susceptible persons. The alternatives to using epinephrine in a life-threatening situation may not be satisfactory. The presence of a sulfite in this product should not deter administration of the drug for treatment of serious allergic or other emergency situations.
Adrenalin (epinephrine injection, USP) should be protected from exposure to light. Do not remove ampoules or syringes from carton until ready to use. The solution should not be used if it is pinkish or darker than slightly yellow or if it contains a precipitate.
Epinephrine is readily destroyed by alkalies and oxidizing agents. In the latter category are oxygen, chlorine, bromine, iodine, permanganates, chromates, nitrites, and salts of easily reducible metals, especially iron.
Usage in Pregnancy
Pregnancy Category C. Adrenalin (epinephrine) has been shown to be teratogenic in rats when given in doses about 25 times the human dose. There are no adequate and well-controlled studies in pregnant women. Adrenalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/29/2008
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