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Anascorp

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Anascorp

Anascorp®
Centruroides (Scorpion) Immune F(ab' )2 (Equine) Injection

DRUG DESCRIPTION

Anascorp [Centruroides (Scorpion) Immune F(ab')2 (Equine) Injection] is a sterile, nonpyrogenic, lyophilized, polyvalent preparation of equine immune globulin F(ab')2 fragments, manufactured from plasma of horses immunized with venom of C. noxius, C.l. limpidus, C.l. tecomanus, and C.s.sujjusus. The product is obtained by pepsin digestion of horse plasma to remove the Fc portion o f immune globulin, followed by fractionation and purification steps. The F(ab')2 content is not less than 85%, F(ab) content is not more than 7%, and the product contains less than 5% intact immunoglobulin. Each vial of Anascorp contains 45-80 milligrams of sodium chloride, 4.3-38.3 milligrams of sucrose, and 6.6-94.9 milligrams of glycine as stabilizers. Trace amounts of pepsin, cresol ( < 0.41 mg/vial), borates ( < 1 mg/vial), and sulfates ( < 1.7 mg/vial) may be present from the manufacturing process. Each vial contains no more than 120 milligrams of protein and will neutralize at least 150 LD50 of Centruroides scorpion venom in a mouse neutralization assay.

The manufacturing procedures that contribute to the reduction of risk of viral transmission include pepsin digestion, ammonium sulfate precipitation/heat treatment, and nanofiltration.

Last reviewed on RxList: 5/27/2016
This monograph has been modified to include the generic and brand name in many instances.

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