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Use with extreme caution in patients with impaired renal function. Close monitoring of hematologic, renal and hepatic status of all patients is essential. These instructions should be thoroughly reviewed before administration of Ancobon (flucytosine) .
Ancobon (flucytosine), an antifungal agent, is available as 250mg and 500mg capsules for oral administration. Each capsule also contains corn starch, lactose and talc. Gelatin capsule shells contain parabens (butyl, methyl, propyl) and sodium propionate, with the following dye systems: 250-mg capsules — black iron oxide, FD&C Blue No. 1, FD&C Yellow No. 6, D&C Yellow No. 10 and titanium dioxide; 500mg capsules — black iron oxide and titanium dioxide. Chemically, flucytosine is 5-fluorocytosine, a fluorinated pyrimidine which is related to fluorouracil and floxuridine. It is a white to off-white crystalline powder with a molecular weight of 129.09 and the following structural formula:
What are the possible side effects of flucytosine (Ancobon)?
If you experience any of the following serious side effects, stop taking flucytosine and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- chest pain;
- yellowing of the skin or eyes;
- little or no urine;
- confusion or hallucinations;
- numbness or tingling; or
- hearing loss.
Other, less serious side effects may be more likely to occur. Continue to take flucytosine and talk to your doctor if you...
What are the precautions when taking flucytosine (Ancobon)?
Before taking flucytosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, decreased bone marrow function, a low number of blood cells (red or white blood cells, platelets), radiation treatment, mineral imbalance (such as low level of potassium in the blood).
Wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been...
Last reviewed on RxList: 10/8/2008
This monograph has been modified to include the generic and brand name in many instances.
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