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Anectine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 7/2/2015

Anectine (succinylcholine chloride) is a skeletal muscle relaxant for intravenous (IV) administration indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Common side effects of Anectine include muscle relaxation resulting in respiratory depression to the point of apnea. Hypersensitivity reactions, including anaphylaxis, may occur in rare instances. Other serious side effects of Anectine include cardiac arrest, life threatening elevation in body temperature, abnormal heart rhythms, fast or slow heart rate, high or low blood pressure, high blood potassium, prolonged slow breathing, increased eye pressure, muscle twitching, jaw rigidity, postoperative muscle pain, breakdown of muscle tissue (rhabdomyolysis), excessive salivation, and rash.

The dosage of Anectine is individualized and determined by the clinician after careful assessment of the patient. Anectine is only administered by a physician. Anectine may interact with promazine, oxytocin, antibiotics, quinidine, beta blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, and terbutaline. Tell your doctor all medications you are taking. Anectine should be given to a pregnant woman only if clearly needed. It is unknown whether Anectine can cause fetal harm. It is not known whether Anectine is excreted in human milk. Consult your doctor before breast-feeding.

Our Anectine (succinylcholine chloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Anectine FDA Prescribing Information: Side Effects
(Adverse Reactions)


Adverse reactions to succinylcholine consist primarily of an extension of its pharmacological actions. Succinylcholine causes profound muscle relaxation resulting in respiratory depression to the point of apnea; this effect may be prolonged. Hypersensitivity reactions, including anaphylaxis, may occur in rare instances. The following additional adverse reactions have been reported: cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia, tachycardia, hypertension, hypotension, hyperkalemia, prolonged respiratory depression or apnea, increased intraocular pressure, muscle fasciculation, jaw rigidity, postoperative muscle pain, rhabdomyolysis with possible myoglobinuric acute renal failure, excessive salivation, and rash.

There have been post-marketing reports of severe allergic reactions (anaphylactic and anaphylactoid reactions) associated with use of neuromuscular blocking agents, including ANECTINE (succinylcholine chloride) . These reactions, in some cases, have been life-threatening and fatal. Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency (see WARNINGS AND PRECAUTIONS).

Read the entire FDA prescribing information for Anectine (Succinylcholine Chloride)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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