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Angeliq Patient Information including How Should I Take

What should I discuss with my doctor before taking drospirenone and estradiol (Angeliq)?

You should not take this medicine if you are allergic to drospirenone or estradiol, or if you have:

  • a bleeding or blood-clotting disorder, or circulation problems;
  • unusual vaginal bleeding that has not been checked by a doctor;
  • kidney disease;
  • liver disease;
  • an adrenal gland disorder;
  • a history of hormone-related cancer such as breast or uterine cancer;
  • if you have had your uterus removed (hysterectomy);
  • if you are pregnant or plan to become pregnant;
  • if you have had a heart attack or stroke; or
  • if you have ever had a blood clot (especially in your lung or your lower body).

To make sure you can safely take drospirenone and estradiol, tell your doctor if you have any of these other conditions:

  • heart disease, high blood pressure;
  • risk factors for coronary artery disease (such as smoking, being overweight, or a family history of coronary artery disease);
  • high cholesterol or triglycerides;
  • diabetes;
  • a thyroid disorder;
  • high levels of calcium, sodium, or potassium in your blood;
  • endometriosis;
  • gallbladder disease;
  • asthma;
  • severe migraines (with aura, numbness, weakness, or vision changes), especially if you are older than 35;
  • a history of jaundice caused by pregnancy or birth control pills;
  • epilepsy or other seizure disorder;
  • hereditary angioedema (an immune system disorder);
  • a history of fibrocystic breast disease, lumps, nodules, or an abnormal mammogram;
  • systemic lupus erythematosus (SLE); or
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Taking the combination of drospirenone and estradiol may reduce this risk. Talk with your doctor about your individual risk, and report any unusual vaginal bleeding right away.

FDA pregnancy category X. Do not use drospirenone and estradiol if you are pregnant or plan to become pregnant. Tell your doctor right away if you become pregnant during treatment.

The hormones in drospirenone and estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast feeding a baby.

How should I take drospirenone and estradiol (Angeliq)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not crush, chew, or break a drospirenone and estradiol tablet. Swallow it whole.

Try to take drospirenone and estradiol at the same time each day.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are taking drospirenone and estradiol.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while taking drospirenone and estradiol.

Store at room temperature away from moisture and heat.

Side Effects Centers

Angeliq - User Reviews

Angeliq User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Angeliq sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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