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Angeliq Patient Information Including Side Effects

Brand Names: Angeliq

Generic Name: drospirenone and estradiol (Pronunciation: droh SPYE re none ES tra dye ole)

What is drospirenone and estradiol (Angeliq)?

Drospirenone is a female hormone that helps regulate ovulation and menstruation.

Estradiol is a female hormone involved in development and maintenance of the female reproductive system.

Drospirenone and estradiol is used to treat the symptoms of menopause such as hot flashes or vaginal changes (itching, burning, dryness, urination problems). It is also used to prevent thinning of the bones (osteoporosis).

Drosperinone and estradiol also treats the symptoms of premenstrual dysphoric disorder (PMDD). The symptoms of PMDD include depression, anxiety, persistent anger or irritability, trouble concentrating, sleep or appetite changes, and feeling out of control. PMDD also includes physical symptoms such as breast tenderness, headache, joint or muscle pain, bloating, and weight gain.

PMDD is not the same condition as premenstrual syndrome (PMS). This medication is not meant to treat PMS.

Drospirenone and estradiol may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of drospirenone and estradiol (Angeliq)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • chest pain;
  • shortness of breath;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • unusual vaginal bleeding;
  • stomach pain, swelling, or tenderness;
  • jaundice (yellowing of the skin or eyes); or
  • breast lump.

Continue using drospirenone and estradiol and talk with your doctor if you have any of these less serious side effects:

  • nausea and vomiting;
  • breast tenderness or enlargement;
  • swelling of your hands or feet;
  • darkened skin, especially on your face;
  • changes in your menstrual periods;
  • headache, migraine, dizziness, or fainting;
  • problems with contact lenses;
  • depression;
  • vaginal yeast infections; or
  • enlargement of uterine fibroids.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the Angeliq (drospirenone and estradiol) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about drospirenone and estradiol (Angeliq)?

Drospirenone may raise potassium levels in your blood. Other medical conditions can also affect potassium levels. Before using drospirenone and estradiol, tell your doctor about all of your current and past medical conditions, and about all the medicines you use.

Stop using this medication and call your doctor at once if you feel short of breath, have sudden numbness or weakness on one side of the body, sudden headache, confusion, or problems with vision, speech, or balance.

Call your doctor right away if you have a breast lump, unusual vaginal bleeding, or jaundice (yellowing of the skin or eyes).

Side Effects Centers

Angeliq - User Reviews

Angeliq User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Angeliq sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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