Angiomax
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Angiomax
ANGIOMAX®
(bivalirudin) for Injection, for Intravenous Use
DRUG DESCRIPTION
Angiomax (bivalirudin) is a specific and reversible direct thrombin inhibitor. The active substance is a synthetic, 20 amino acid peptide. The chemical name is D-phenylalanyl-L-prolyl-L-arginyl-L-prolyl-glycylglycyl-glycyl-glycyl-L-asparagyl-glycyl-L-aspartyl-L-phenylalanyl-L-glutamyl-L-glutamyl-L-isoleucyl-L-prolyl-L-glutamyl-L-glutamyl-L-tyrosyl-L-leucine trifluoroacetate (salt) hydrate (Figure 1). The molecular weight of Angiomax (bivalirudin) is 2180 daltons (anhydrous free base peptide).
Angiomax (bivalirudin) is supplied in single-use vials as a white lyophilized cake, which is sterile. Each vial contains 250 mg bivalirudin, 125 mg mannitol, and sodium hydroxide to adjust the pH to 5-6 (equivalent of approximately 12.5 mg sodium). When reconstituted with Sterile Water for Injection, the product yields a clear to opalescent, colorless to slightly yellow solution, pH 5-6.
Figure 1. Structural Formula for Bivalirudin
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What are the possible side effects of bivalirudin (Angiomax)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- sudden numbness or weakness, especially on one side of the body;
- sudden headache, confusion, problems with vision, speech, or balance;
- pain or swelling in one or both legs;
- any bleeding that will not stop;
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like coffee...
Read All Potential Side Effects and See Pictures of Angiomax »
Last reviewed on RxList: 7/20/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Angiomax Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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