November 29, 2015


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Are there any interactions with medications?

Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Annatto might increase how quickly the liver breaks down some medications. Taking annatto along with some medications that are broken down by the liver might decrease the effectiveness of some medications. Before taking annatto, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Medications that might be affected include chlorzoxazone, theophylline, and bufuralol.

Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Annatto might increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. By increasing or decreasing blood sugar, annatto might decrease the effectiveness of diabetes medications or increase the risk of your blood sugar going too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing considerations for Annatto.

The appropriate dose of annatto depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for annatto. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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