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Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge.
The physician should instruct relatives accordingly.
Disulfiram is an alcohol antagonist drug.
Chemical Name: bis(diethylthiocarbamoyl) disulfide.
C10H20N2S4 M.W. 296.54
Disulfiram occurs as a white to off-white, odorless, and almost tasteless powder, soluble in water to the extent of about 20 mg in 100 mL, and in alcohol to the extent of about 3.8 g in 100 mL.
Each tablet for oral administration contains 250 mg or 500 mg disulfiram, USP. Tablets also contain colloidal silicon dioxide, anhydrous lactose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid.
What are the possible side effects of disulfiram (Antabuse)?
Severe and sometimes fatal liver problems have occurred in patients taking disulfiram even without a prior history of liver problems.
If you experience any of the following serious side effects, stop taking disulfiram and seek emergency medical attention:
- an allergic reaction (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or hives);
- extreme tiredness;
- dark urine;
- yellowing of the skin or eyes (jaundice);
- large appetite changes;
- weakness, dizziness or loss of coordination;...
What are the precautions when taking disulfiram (Antabuse)?
Before taking disulfiram, tell your doctor or pharmacist if you are allergic to it; or to thiuram or thiuram-related chemicals (found in pesticides and rubber); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe heart/blood vessel disease (e.g., coronary artery disease), certain mental/mood condition (psychosis).
Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, underactive thyroid (hypothyroidism), brain disorders (e.g., seizures,...
Last reviewed on RxList: 4/13/2009
This monograph has been modified to include the generic and brand name in many instances.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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