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Nausea, dizziness, and vertigo were noted in healthy volunteers receiving 50 and 100 mg/kg doses of Antizol (fomepizole) (at plasma concentrations of 290-520 µmol/L, 23.8-42.6 mg/L). These doses are 3-6 times the recommended dose. This dose-dependent CNS effect was short-lived in most subjects and lasted up to 30 hours in one subject.

Antizol (fomepizole) is dialyzable, and hemodialysis may be useful in treating cases of overdosage.

Antizol (fomepizole) should not be administered to patients with a documented serious hypersensitivity reaction to Antizol (fomepizole) or other pyrazoles.

Last reviewed on RxList: 11/6/2008
This monograph has been modified to include the generic and brand name in many instances.