"In a response to mounting evidence, the US Food and Drug Administration (FDA) announced that the diabetes drug metformin can be used safely in patients with mild and, in some cases, moderate kidney impairment after decades of warning against it. "...
(Generic versions may still be available.)
DOSAGE AND ADMINISTRATION
200-400 mg daily in two divided doses, with meals or milk, gradually increasing when necessary to full maintenance dosage in one week.
400mg daily, given in two divided doses, as above. This dosage may be increased to 800 mg daily, if necessary, and may sometimes be reduced to as low as 200 mg daily after the blood urate level has been controlled. Treatment should be continued without interruption even in the presence of acute exacerbations, which can be concomitantly treated with phenylbutazone or colchicine. Patients previously controlled with other uricosuric therapy may be transferred to Anturane (sulfinpyrazone) at full maintenance dosage.
Tablets 100 mg round, white, scored (imprinted CIBA 41)
Bottles of 100 NDC 0083-0041-30
Capsules 200 mg green (imprinted Anturane (sulfinpyrazone) 200 CIBA 168)
Bottles of 100 NDC 0083-0168-30
Do not store above 86° F (30° C).
Dispense in tight container (USP).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Anturane Information
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