Anturane (Sulfinpyrazone) Drug Information: Side Effects and Drug Interactions

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May 24, 2012

Anturane

Gout »

What is gout? What is hyperuricemia?

Gout is a disease that results from an overload of uric acid in the body. This overload of uric acid leads to the formation of tiny crystals of urate that deposit in tissues of the body, especially the joints. When crystals form in the joints, it causes recurring attacks of joint inflammation (arthritis). Gout is considered a chronic and progressive disease. Chronic gout can also lead to deposits of hard lumps of uric acid in the tissues, particularly in and around the joints and may cause joint destruction, decreased kidney function, and kidney stones (nephrolithiasis).

Gout has the unique distinction of being one of the most frequently recorded medical illnesses throughout history. It is often related to an inherited abnormality in the body's ability to process uric acid. Uric acid is a breakdown product of purines that are part of many foods we eat. An abnormality in handling uric acid can cause attacks of p...

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Anturane

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

SIDE EFFECTS

The most frequently reported adverse reactions with Anturane (sulfinpyrazone) have been upper gastrointestinal disturbances. In these patients it is advisable to administer the drug with food, milk, or antacids. Despite this precaution, Anturane (sulfinpyrazone) may aggravate or reactivate peptic ulcer.

Rash has been reported. In most instances, this reaction did not necessitate discontinuance of therapy. In general, Anturane (sulfinpyrazone) has not been observed to affect electrolyte balance.

Blood dyscrasias (anemia, leukopenia, agranulocytosis, thrombocytopenia, and aplastic anemia) have rarely been reported. There has also been a published report associating Anturane (sulfinpyrazone) , administered concomitantly with other drugs including colchicine, with leukemia following long term treatment of patients with gout. However, the circumstances involved in the two cases reported are such that a cause-and-effect relationship to Anturane (sulfinpyrazone) has not been clearly established.