"A deeper dive into data from the Trial Evaluating Cardiovascular Outcomes With Sitagliptin (TECOS) with the type 2 diabetes drug sitagliptin (Januvia, Merck), confirming that the dipeptidyl peptidase-4 (DPP-4) is not associated with any "...
(Generic versions may still be available.)
Studies on the teratogenicity of pyrazole compounds in animals have yielded inconclusive results. Up to the present time, however, there have been no reported cases of human congenital malformation proved to be due to the use of the drug.
It is suggested that Anturane (sulfinpyrazone) be used with caution in pregnant women, weighing the potential risks against the possible benefits.
As with all pyrazole compounds, patients receiving Anturane (sulfinpyrazone) should be kept under close medical supervision and periodic blood counts are recommended. It may be administered with care to patients with a history of healed peptic ulcer.
Recent reports have indicated that Anturane (sulfinpyrazone) potentiates the action of certain sulfonamides, such as sulfadiazine and sulfisoxazole. In addition, other pyrazole compounds (phenylbutazone) have been observed to potentiate the hypoglycemic sulfonylurea agents, as well as insulin. In view of these observations, it is suggested that Anturane (sulfinpyrazone) be used with caution in conjunction with sulfa drugs, the sulfonylurea hypoglycemic agents and insulin.
Because Anturane (sulfinpyrazone) is a potent uricosuric agent, it may precipitate urolithiasis and renal colic, especially in the initial stages of therapy. For this reason, an adequate fluid intake and alkalinization of the urine are recommended. In cases with significant renal impairment, periodic assessment of renal function is indicated. Occasional cases of renal failure have been reported; but a cause-and-effect relationship has not always been clearly established.
Salicylates antagonize the uricosuric action of Anturane (sulfinpyrazone) and for this reason their concomitant use is contraindicated in gouty arthritis.
Anturane (sulfinpyrazone) may accentuate the action of coumarin-type anticoagulants and further depress prothrombin activity when these medications are employed simultaneously.
Safety and effectiveness in pediatric patients have not been established.
In the initial stages of therapy, because of the marked ability of Anturane (sulfinpyrazone) to mobilize urates, acute attacks of gouty arthritis may be precipitated.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Anturane Information
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