Yohimbine is a 3a-15a-20(beta)-17a- hydroxy Yohimbine-16a-carboxylic acid methyl ester. The alkaloid is found in Rubaceae and related trees and is also found in Rauwolfia Serpentina (L) Benth.

Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. It is a crystalline powder, odorless. Each compressed caplet contains 5.4 mg (1/12 gr.) of Yohimbine Hydrochloride.

 

Last updated on RxList: 12/8/2004

APHRODYNE® is indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins (18 mg/day).

Experimental dosage reported in treatment of erectile impotence: ^1,3,4 1 caplet (5.4mg) 3 times a day, to adult males taken orally. Occasional side effects reported with this dosage are nausea, dizziness or nervousness. In the event of side effects dosage is to be reduced to 1/2 caplet 3 times a day, followed by gradual increases to 1 caplet 3 times a day. Reported therapy not more than 10 weeks. ³

APHRODYNE® scored caplets are aqua, debossed with APHRO DYNE. They are available in bottles of 100 NDC 0076-0401-03) and 1000 (NDC 0076-0401-04).

MANUFACTURED FOR:
Star Pharmaceuticals, Inc.

Last updated on RxList: 12/8/2004

Yohimbine readily penetrates the CNS and produces a complex pattern of responses in lower doses than required to produce peripheral (alpha)-adrenergic blockage. These include anti-diuresis, a general picture of central excitation including elevated blood pressure and heart rate, increased motor activity, irritability and tremor. Sweating, nausea and vomiting are common after parenteral administration of the drug. ^1,2 Also dizziness, headache, and skin flushing have been reported. ^1,3

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Last updated on RxList: 12/8/2004

Generally, this drug is not proposed for use in females and certainly must not be used during pregnancy. Neither is this drug proposed for use in pediatric, geriatric or cardio-renal patients with gastric or duodenal ulcer history. Nor should it be used in conjunction with mood-modifying drugs such as antidepressants or in psychiatric patients in general.

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Last updated on RxList: 12/8/2004

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Renal diseases, and patients sensitive to the drug. In view of the limited and inadequate information at hand, no precise tabulation can be offered of additional contraindications.

 

Last updated on RxList: 12/8/2004

Yohimbine blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of short duration. Yohimbine's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) and decrease sympathetic (adrenergic) activity. It is to be noted that in male sexual performance, erection is linked to cholinergic activity and to alpha-2 adrenergic blockade which may theoretically result in increased penile inflow, decreased penile outflow or both.

Yohimbine exerts a stimulating action on the mood and may increase anxiety. Such actions have not been adequately studied or related to dosage although they appear to require high doses of the drug. Yohimbine has a mild anti-diuretic action, probably via stimulation of hypothalmic center and release of posterior pituitary hormone.

Reportedly Yohimbine exerts no significant influence on cardiac stimulation and other effects mediated by (beta)-adrenergic receptors. Its effect on blood pressure, if any, would be to lower it; however, no adequate studies are at hand to quantitate this effect in terms of Yohimbine dosage.

Last updated on RxList: 12/8/2004

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Last updated on RxList: 12/8/2004

IMPORTANT NOTE: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product is safe, effective, or appropriate for you.

YOHIMBINE - ORAL

(yo-HIM-bean)

COMMON BRAND NAME(S): Yocon

USES: This medication has been used to widen (dilate) the pupil of the eye. Yohimbine has been used in the past to treat male sexual function problems, but this use is no longer recommended. Yohimbine belongs to a class of drugs known as alpha-2 adrenergic blockers. It has the effect of relaxing certain muscles of blood vessels and the pupil.

This medication should not be used in women.

HOW TO USE: Take this medication by mouth, usually 3 times daily or exactly as directed by your doctor.

Dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Tell your doctor if your condition persists or worsens.

SIDE EFFECTS: Nausea, dizziness, and nervousness may occur. Other side effects may include headache, sweating, vomiting, unusually fast heartbeat, and skin flushing. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., anxiety), feelings of restlessness/agitation/jitteriness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching, swelling, severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contact your doctor for medical advice about side effects. The following numbers do not provide medical advice, but in the US you may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088. In Canada, you may call Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking yohimbine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney problems, severe mental/mood disorder (e.g., psychosis, anxiety/panic disorder).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/duodenal ulcer, other mental/mood disorders (e.g., depression).

This drug may make you dizzy or drowsy. Use caution while driving, using machinery, or doing any activity that requires alertness. Limit alcoholic beverages.

This medication is not recommended for use in the elderly.

This medication is not recommended for use in children.

Since this medication is not intended for use in women, avoid accidental use. Contact your doctor immediately if you accidentally take this medication while pregnant.

It is not known whether this drug passes into breast milk. Avoid accidental use while breast-feeding. Consult your doctor immediately if you accidentally take this medication while breastfeeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.

Keep all medical appointments so that your doctor can periodically monitor your progress or check for side effects.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised July 2008 Copyright(c) 2008 First DataBank, Inc.