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Apidra

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Apidra

Apidra

PATIENT INFORMATION

APIDRA
(uh PEE druh)
(insulin glulisine [recombinant DNA origin]) Solution for Injection

Read the Patient Information that comes with APIDRA before you start taking it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your healthcare provider about your diabetes or treatment. If you have questions about APIDRA or about diabetes, talk with your healthcare provider.

What is APIDRA?

APIDRA is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

It is not known if APIDRA is safe or effective in:

Who should NOT take APIDRA?

Do not take APIDRA:

  • when your blood sugar is too low (hypoglycemia). See the section, “What are the possible side effects of APIDRA?”
  • if you are allergic to any of the ingredients in APIDRA. See the end of this leaflet for a complete list of ingredients. Ask your healthcare provider if you are not sure.

What should I tell my healthcare provider before taking APIDRA?

Medical conditions can affect your insulin needs. Tell your healthcare provider about all of your medical conditions, including if you:

  • have liver or kidney problems.
  • are pregnant, plan to become pregnant, or are breast-feeding. It is not known if APIDRA will harm your unborn baby or nursing child. You and your healthcare provider should talk about the best way to manage your diabetes while you are pregnant or breast-feeding. It is especially important to keep good control of your blood sugar during pregnancy.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of your medicines with you and show it to your healthcare provider and pharmacist when you get a new medicine.

How should I take APIDRA?

  • Take APIDRA exactly as prescribed.
  • Do not make any changes to your dose or type of insulin unless told to do so by your healthcare provider.
  • Know your insulin. Make sure you know:
    • the type and strength of insulin prescribed for you
    • the amount of insulin you take
    • the best time for you to take your insulin. This may change if you take a different type of insulin or if the way you give your insulin changes for example, using an insulin pump instead of giving injections under the skin (subcutaneous injections).
  • APIDRA starts working faster than regular insulin, but does not work as long.
  • APIDRA is usually used with a longer-acting insulin when given by injection under the skin (subcutaneous), or by itself when using an insulin pump.
  • Read the instructions for use that come with your APIDRA. Talk to your healthcare provider if you have any questions. Your healthcare provider should show you how to inject APIDRA before you start taking it.
  • Your healthcare provider will prescribe the best type of APIDRA for you. APIDRA is available in:
    • 3 mL cartridge system for use in OptiClik® Insulin Delivery Device
    • 3 mL SoloStar® prefilled pen
    • 10 mL vials
      You need a prescription to get APIDRA. Always be sure you receive the right insulin from the pharmacy.
  • Check your blood sugar level before each use of APIDRA. Ask your healthcare provider what your blood sugars should be and when you should check your blood sugar levels.
  • Check the label to make sure you have the correct insulin type. This is especially important if you also take long-acting insulin.
  • APIDRA should look clear and colorless. Do not use APIDRA if it looks cloudy, colored, or has particles in it. Talk with your pharmacist or healthcare provider if you have any questions.
  • If you take to much APIDRA, your blood sugar may fall low (hypoglycemia). You can treat mild low blood sugar (hypoglycemia) by drinking or eating something sugary right away.
  • Do not share needles, insulin pens or syringes with others.

Your dose of APIDRA may need to be changed because of:

  • illness
  • change in diet
  • stress
  • change in physical activity or exercise
  • other medicines you take
  • travel

Check your blood sugar and stay on the diet and exercise plan as prescribed by your healthcare provider.

What should I consider while taking APIDRA?

  • Alcohol may affect your blood sugar when you take APIDRA
  • Driving and operating machinery. You may have trouble paying attention or reacting if you have low blood sugar (hypoglycemia). Be careful when you drive a car or operate machinery. Ask your healthcare provider if it is alright for you to drive if you have:
    • low blood sugar (hypoglycemia)
    • decreased or no warning signs of low blood sugar

What are the possible side effects of APIDRA?

APIDRA can cause serious side effects, including:

  • Low blood sugar (hypoglycemia). Symptoms of low blood sugar may include:
    • feeling anxious, or irritable, mood changes
    • trouble concentrating or feeling confused
    • tingling in your hands, feet, lips, or tongue
    • feeling dizzy, light-headed, or drowsy
    • nightmares or trouble sleeping
    • headache
    • blurred vision
    • slurred speech
    • a fast heart beat
    • sweating
    • shakiness
    • walking unsteady

Very low blood sugar (hypoglycemia) can cause unconsciousness (passing out), seizures, and death. Talk to your healthcare provider about how to tell if you have low blood sugar and what to do if this happens while taking APIDRA. Know your symptoms of low blood sugar. Follow your healthcare provider's instructions for treating your low blood sugar.

Talk to your healthcare provider if low blood sugar is a problem for you. Your dose of APIDRA may need to be changed.

  • Serious allergic reactions.
    Get medical help right away if you have any of these symptoms of a severe allergic reaction:
    • a rash all over your body
    • shortness of breath
    • trouble breathing (wheezing)
    • fast pulse
    • sweating
    • feel faint (due to low blood pressure)
  • Low potassium in your blood. Your doctor will check you for this.
    Common side effects include:
  • Reactions at the injection site (local allergic reaction). You may get redness, swelling and itching at the injection site. If you keep having skin reactions or they are serious talk to your healthcare provider.
  • Skin thickening or pits at the injection site. Do not inject insulin into skin where this has happened. Choose an injection area (upper arm, thigh, or stomach area). Change injection sites within the area you choose with each dose. Do not inject into the exact same spot for each injection.
  • Weight gain

Tell your healthcare provider about any side effect that bothers you or that does not go away. These are not all of the possible side effects of APIDRA.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1800-332-1088.

How should I store APIDRA?

  • See the Patient Instructions for Use that come with your APIDRA for specific storage instructions.

Unopened APIDRA:

  • Do not use APIDRA after the expiration date stamped on the label.
  • Keep all unopened APIDRA in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Do not freeze. Do not use APIDRA if it has been frozen.
  • Keep APIDRA away from direct heat and light.
  • Unopened vials, cartridge systems and SoloStar that were not kept in a refrigerator must be used within 28 days after opening.

General Information about APIDRA

Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use APIDRA for a condition for which it was not prescribed. Do not give APIDRA to other people, even if they have the same symptoms you have. It may harm them.

This leaflet summarizes the most important information about APIDRA. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider for information about APIDRA that is written for healthcare providers. For more information about APIDRA call 1-800-633-1610 or go to www.apidra.com.

What are the ingredients in APIDRA?

Active ingredient: insulin glulisine

Inactive ingredients: metacresol, tromethamine, sodium chloride, polysorbate 20, water for injection, hydrochloric acid or sodium hydroxide

ADDITIONAL INFORMATION

DIABETES FORECAST is a national magazine designed especially for patients with diabetes and their families and is available by subscription from the American Diabetes Association, (ADA), P.O. Box 363, Mt. Morris, IL 61054-0363, 1-800-DIABETES (1-800-342-2383). You may also visit the ADA website at www.diabetes.org.

Another publication, COUNTDOWN, is available from the Juvenile Diabetes Research Foundation International (JDRF), 120 Wall Street, 19th Floor, New York, New York 10005, 1800-JDF-CURE (1-800-533-2873). You may also visit the JDRF website at www.jdf.org. To get more information about diabetes, check with your healthcare provider or diabetes educator or visit www.DiabetesWatch.com.

For more information about APIDRA or OptiClik® call 1-800-633-1610 or visit www.apidra.com or www.opticlik.com.

PATIENT INSTRUCTIONS FOR USE

APIDRA 10 mL vial (100 Units/mL)

This Instructions for Use has two parts:

Part 1 - Use with a syringe

Part 2 - Use with an external insulin infusion pump

Be sure to read, understand and follow these instructions before taking APIDRA.

Part 1 Use with a syringe

If you will give yourself subcutaneous injections of APIDRA:

  • You should take APIDRA within 15 minutes before a meal or within 20 minutes after starting a meal.
  • Do not inject APIDRA if you are not going to eat within 15 minutes.
  • Inject APIDRA into the skin of your upper arm, thigh, or stomach area. Do not inject APIDRA into a vein or into a muscle.
  • Choose an injection area (upper arm, thigh, or stomach area). C hange injection sites within the area you choose with each dose. Do not inject into the exact same spot for each injection.
  • Do not mix APIDRA with insulins other than NPH, for subcutaneous injections. If mixing APIDRA with NPH insulin, draw up APIDRA into the syringe first. Inject the mixture right away.
  • Use the needles and syringes prescribed by your healthcare provider.

Before every injection make sure you have the following items:

  • Alcohol swabs
  • Needle and syringe
  • Insulin vial
  • Puncture resistant container. See “How do I dispose of used needles and syringes?”.

Drawing the insulin into a syringe

1. Use a new syringe each time you give an injection of APIDRA.

Preparing for an injection

2. Wash your hands with soap and water. Before you start to prepare your injection, check the label to make sure that you are taking the right type of insulin.

3. Look at the APIDRA in the vial. It should look clear. Do not use this vial of APIDRA if the solution is colored, or cloudy, or if you see particles in it.

4. If you are using a new vial, remove the protective cap. Do not remove the stopper.

Rremove the protective cap - Illustration

5. Wipe the rubber stopper with an alcohol swab. You do not have to shake the vial of APIDRA before use.

Wipe the rubber stopper - Illustration

6. Use the needles and syringes prescribed by your healthcare provider. APIDRA 10 mL vials come with 100 units of insulin in 1 mL of APIDRA.

7. Use a new needle and syringe for each injection. Use disposable syringes and needles only one time.

8. Draw air into the syringe equal to the insulin dose prescribed by your healthcare provider.

Draw air into the syringe equal to the insulin dose prescribed - Illustration

9. Put the needle through the rubber stopper of the vial and push the plunger to inject the air into the vial.

Put the needle through the rubber stopper - Illustration

10. Leave the syringe in the vial and turn both upside down. Hold the syringe and vial firmly in one hand.

11. Make sure the tip of the needle is in the insulin solution. With your free hand, pull back on the plunger to draw the correct dose of insulin into the syringe.

Pull back on the plunger to draw the correct dose - Illustration

12. Before you take the needle out of the vial, check the syringe for air bubbles. If you see bubbles in the syringe, hold the syringe straight up and tap the side of the syringe with your finger a few times to make any air bubbles float to the top. Gently push the air bubbles out with the plunger and draw insulin back into the syringe until you have the correct dose. If you are mixing APIDRA with NPH insulin, check with your healthcare provider on how to mix it the right way.

Tap the side of the syringe - Illustration

13. Remove the needle from the vial. Do not let the needle touch anything. You are now ready to inject.

Giving the injection

Do the injection exactly as shown to you by your healthcare provider. Inject APIDRA under your skin.

14. Choose an injection area (for example upper arm, thigh or stomach area). Change injection sites within the area you choose. Do not inject in the same spot.

15. Clean the area with an alcohol swab. Let the injection site dry before you inject.

Clean the area - Illustration

16. Pinch the skin. Insert the needle into the skin. Release the skin.

17. Inject the dose by slowly pushing in the plunger of the syringe all the way, making sure you have injected all the insulin. Keep the needle in the skin for at least 10 seconds.

Inject the dose - Illustration

Pull the needle out of your skin, gently press the injection site with a finger for several seconds. Do not rub the area.

18. Do not recap the needle. Recapping can lead to a needle stick injury and passing of infection. See “How do I dispose of used needles and syringes?”. If your injection is given by another person, this person must also be careful to prevent accidental needle stick injury and passing infections.

How do I dispose of used needles and syringes?

19. Check with your healthcare provider's office for instructions about the right way to dispose of used needles and syringes. There may be local or state laws about how to dispose of used needles and syringes. Do not dispose of used needles or syringes in household trash and do not recycle them.

20. Put used needles and syringes in a container specially made for throwing away syringes and needles (called a “sharps” container) or a hard plastic container with a screw-on cap or a metal container with a plastic lid labeled “Used Syringes”. These containers should be sealed and dispose of the right way.

See “How should I store APIDRA?” in the Patient Information leaflet that comes With APIDRA for complete instructions on how to store APIDRA vials.

Part 2 - Use with an external insulin pump:

Be sure to read, understand, and follow these instructions before using APIDRA with an external insulin infusion pump. Always read the instruction manual for your pump. These instructions may differ from the instructions that accompany your insulin infusion pump. When you use Apidra in the pump system, it is important that you always follow these Apidra specific instructions. Failure to follow the Apidra specific instructions may lead to serious adverse events.

If you will be using an insulin pump:

  • APIDRA should be given into the stomach area.
  • Change injection sites in the stomach area.
  • Do not mix APIDRA with other insulins and do not dilute APIDRA.
  • Use only insulin pumps that have been specially tested with APIDRA. Follow your healthcare provider or pharmacist instructions for which insulin pumps may be used.
  • Change the infusion set (reservoir, tubing, and catheter), and the APIDRA in the reservoir at least every 2 days (48 hours). Change all of these parts sooner if they have been exposed to temperatures higher than 98.6°F (37°C).

Important information about using APIDRA with an external insulin infusion pump

  • Do not mix APIDRA with any other insulin or liquid when used in a pump.
  • If your APIDRA infusion pump set is not working the right way or in case of handling errors, you may not get the right amount of insulin that can cause:
    • low blood sugar (hypoglycemia)
    • high blood sugar (hyperglycemia)
    • high amounts of sugar and ketones in your blood or urine
    • build-up of acid in your blood because your body is breaking down fat instead of sugar (diabetic ketoacidosis)
  • You must have an alternative insulin delivery system in case of pump failure.
  • When you start using APIDRA by infusion pump, your insulin dose may need to be adjusted. Check with your healthcare provider before making any changes to your insulin dose.

How to use APIDRA with an external insulin infusion pump?

  • Check with your healthcare provider or pharmacist to see if your pump and infusion set can be used with APIDRA. See the instruction manual of your specific pump on proper use of insulin in a pump. Call your healthcare provider if you have questions about using the pump.
  • Change the infusion set, reservoir with insulin, and injection site:
    • at least every 48 hours, change more often than every 48 hours if you have high blood sugar (hyperglycemia), or the pump alarm sounds.
    • if the insulin has been in temperatures over 98.6°F (37°C). Dark colored pump cases or sport covers can increase this type of heat. The location where the pump is worn may affect the temperature.

If you get reactions at the injections infusion site you may need to change infusion sites more often.

If your APIDRA infusion pump is not working the right way, follow these steps:

  • Use insulin from a new vial of APIDRA if infusion pump alarms do not respond to all of the following:
    • a repeat injection or bolus of APIDRA
    • a change in the infusion set and the reservoir
    • a change in the infusion injection site
  • If the same problems happen again, do not use your infusion pump with APIDRA. You may need to restart insulin injections with syringes and needles.
    • Contact your healthcare provider right away.
    • See section I of the Instructions for Use (“Use with a syringe”) for the steps for giving injections of APIDRA using syringes and needles.
    • Continue to check your blood sugar often.

How should I store APIDRA 10 mL vial?

  • Keep in the refrigerator or below 77°F (25°C).
  • Keep vials away from direct heat and light.
  • Dispose of any opened vial after 28 days after the first use, even if there is insulin left in the vial.

Rev. September 2013. sanofi-aventis U.S. LLC Bridgewater NJ 08807 A SANOFI COMPANY

APIDRA® SoloStar®
(insulin glulisine [rDNA origin] injection) 3 mL prefilled pen

Patient Instructions for Use

Be sure that you read, understand and follow these instructions before you use your APIDRA SoloStar®. Talk with your healthcare provider about the right way to use your APIDRA SoloStar before you use it for the first time. Keep this leaflet in case you need to look at it again later.

APIDRA SoloStar should not be used by people who are blind or have severe vision problems, without the help of a person who has good eyesight and who is trained to use the APIDRA SoloStar the right way.

APIDRA SoloStar is a disposable prefilled pen used to inject APIDRA. Each APIDRA SoloStar has 300 units of insulin which can be used for many doses. You can select a dose from 1 to 80 units. The pen plunger moves with each dose. The plunger will only move to the end of the cartridge when 300 units of insulin have been given.

APIDRA SoloStar disposable prefilled pen - Illustration

If you will give yourself subcutaneous injections of APIDRA:

  • You should take APIDRA within 15 minutes before a meal or within 20 minutes after starting a meal.
  • Do not inject APIDRA if you are not going to eat within 15 minutes.
  • Inject APIDRA into the skin of your upper arm, thigh, or stomach area. Do not inject APIDRA into a vein or into a muscle.
  • Choose an injection area (upper arm, thigh, or stomach area). Change injection sites within the area you choose with each dose. Do not inject into the exact same spot for each injection.

Important information for use of APIDRA SoloStar:

  • Use a new needle for each injection. APIDRA Solostar may be used with pen needles from Becton Dickinson and Company, Ypsomed and Owen Mumford. Contact your healthcare provider for further information.
  • Do a safety test before each injection. (See step 3.)
  • Do not share your APIDRA SoloStar with others even if they have diabetes.
  • If your injection is given by another person, this person must be careful to avoid accidental needle stick injury and prevent passing (transmission of) infection.
  • Do not use APIDRA SoloStar if it is damaged or if you are not sure that it is working correctly.
  • Always carry an extra APIDRA SoloStar prefilled pen in case your APIDRA SoloStar is lost or damaged.

Step 1. Preparing for an injection

Make sure you have the following items:

  • Apidra SoloStar
  • Pen needles
  • Alcohol swab
  • Puncture resistant container. See “How do I dispose of used needles and APIDRA SoloStar?”.

Check the label on your APIDRA SoloStar to make sure you have the right insulin. The APIDRA Solostar is blue. It has a dark blue injection button with a raised ring on the top.

Check the expiration date, located on the carton or the label of your APIDRA SoloStar, to make sure the date has not passed. Do not use an APIDRA SoloStar if the date has passed.

Take off the pen cap.

Look at the insulin in your APIDRA SoloStar. Check to make sure that the insulin looks clear. Do not use this APIDRA SoloStar if the insulin is cloudy, colored, or has particles in it.

Step 2. Attaching the needle

Always use a new sterile needle for each injection to help prevent contamination, and potential needle blocks.

Read the pen needle “Instructions for Use” before you use them.

Please note: Pen needles may look different. The pen needles shown are for illustrative purposes only.

A. Wipe the Rubber Seal with alcohol.

B. Remove the protective seal from the new pen needle.

C. Line up the needle with the pen, and keep it straight as you attach it (screw or push on, depending on the needle type).

Line up the needle with the pen - Illustration

  • If you do not keep the needle straight while you attach it this can damage the rubber seal, and cause leakage of insulin, or break the needle.

Damage can be caused when not lined up - Illustration

Step 3. Doing a Safety test

Do a safety test before each injection to make sure that you get the correct dose of APIDRA. The safety test:

  • makes sure that the pen and needle work properly
  • removes air bubbles

A. Select a dose of 2 units by turning the dosage selector.

Select a dose - Illustration

B. Take off the outer needle cap and keep it to remove the used needle after injection. Take off the inner needle cap and dispose of it.

Take off the outer needle cap - Illustration

C. Hold the pen with the needle pointing upwards.

D. Tap the insulin reservoir so that any air bubbles rise up towards the needle.

E. Press the injection button all the way in. Check if insulin comes out of the needle tip.

Check if insulin comes out - Illustration

You may have to do the safety test more than once before you see the insulin.

  • If no insulin comes out, check for air bubbles and repeat the safety test two more times to remove them.
  • If still no insulin comes out, the needle may be blocked. Change the needle and try again.
  • If no insulin comes out after changing the needle, your APIDRA SoloStar may be damaged. Do not use this APIDRA SoloStar.

Step 4. Selecting your dose

Select the APIDRA dose prescribed by your healthcare provider. You can select the insulin dose in steps of 1 unit, from a minimum of 1 unit to a maximum of 80 units. If you need a dose larger than 80 units, you should give it as two or more injections.

A. Check that the dose window shows “0” after the safety test.

B. Select your needed dose (in the example below, the selected dose is 30 units). If you turn past your dose, you can turn back down.

Select your needed dose - Illustration

  • Do not push the injection button while turning, insulin will come out.
  • You cannot turn the dosage selector passed the number of units left in the pen. Do not force the dosage selector to turn. In this case, either you can inject the amount of insulin that is still in the pen and finish your dose with a new APIDRA SoloStar or you can use a new APIDRA SoloStar for your full dose.

Step 5. Giving the injection

A. Give the injection exactly as shown to you by your healthcare provider.

B. Insert the needle into your skin.

Insert the needle into your skin - Illustration

C. Inject the dose by pressing the injection button in all the way. Only push the injection button when you are ready to inject. The number in the dose window will return to “0” as you inject.

Inject the dose - Illustration

D. Keep the injection button pressed all the way in. Slowly count to 10 before you take the needle out of your skin. This will make sure that the full dose has been given.

Step 6. Removing and disposing of the pen needle

Always remove the pen needle after each injection and store your APIDRA SoloStar without a needle attached. This helps prevent:

  • Contamination and infection
  • Air from getting into the insulin reservoir and leakage of insulin. This will help to make sure you inject the right dose of insulin.

A. Follow the instructions from your healthcare provider when removing and disposing of the needle. For example “scoop” the outer needle cap back on the needle and use it to unscrew the used needle from the pen. To lessen the risk of accidental needle stick injury and passing infection:

  • do not recap needles with your fingers
  • never replace the inner needle cap.
    If your injection is given by another person, this person must also be careful when removing and disposing of the needles to prevent accidental needle stick injury and passing infection.

B. Dispose of the needle the right way into your special puncture resistant container (See “How Do I Dispose of used needles and APIDRA SoloStar?”).

C. Always put the pen cap back on the pen, then store the APIDRA SoloStar until your next injection.

How do I dispose of used needles and APIDRA SoloStar?

  • Check with your healthcare provider for instructions about the right way to dispose of used needles and APIDRA SoloStar s. There may be local or state laws about how to throw away used needles and APIDRA SoloStar. Do not dispose of used needles or APIDRA SoloStar in household trash and do not recycle them.
  • Put used needles and used empty APIDRA SoloStar in a container made specially for disposing of used syringes and needles (called a “sharps” container) or a hard plastic container (such as empty detergent bottles),with a screw-on cap, or metal container with a plastic lid labeled “Used Syringes”. These containers should be sealed and disposed of the right way.

How should I Store APIDRA SoloStar?

  • Do not refrigerate APIDRA SoloStar after first use.
  • Keep at room temperature below 77°F (25°C).
  • Dispose of any opened APIDRA SoloStar 28 days after first use.

Maintenance

  • Protect your APIDRA SoloStar from dust and dirt.
  • You can clean the outside of your APIDRA SoloStar by wiping it with a damp cloth.
  • Do not soak, wash or lubricate the pen as this may damage it.
  • Handle your APIDRA SoloStar with care. Avoid situations where your APIDRA SoloStar might be damaged. If you are concerned that your APIDRA SoloStar may be damaged, use a new one.

If you have any questions about APIDRA SoloStar or about diabetes, ask your healthcare provider, go to www.apidra.com or call sanofi-aventis U.S. at 1-800-633-1610.

PATIENT INSTRUCTIONS FOR USE

APIDRA 3 mL cartridge system (100 Units/mL)

Be sure to read, understand, and follow these instructions before using your APIDRA® 3 mL cartridge system. Also read and follow the step-by-step instructions in the “OptiClik® Instructions for Use Leaflet” that comes with OptiClik. If you do not follow the instructions, you may take too much or too little insulin. Your healthcare provider should show you how to use the APIDRA 3 mL cartridge system and OptiClik to inject APIDRA before you use it for the first time. Ask your healthcare provider if you have any questions.

Important Information

If you will give yourself subcutaneous injections of APIDRA:

  • You should take APIDRA within 15 minutes before a meal or within 20 minutes after starting a meal.
  • Do not inject APIDRA if you are not going to eat within 15 minutes.
  • Inject APIDRA into the skin of your upper arm, stomach area, or thigh. Do not inject APIDRA into a vein or into a muscle.
  • Choose an injection area (upper arm, thigh, or stomach area). Change injection sites within the area you choose with each dose. Do not inject into the exact same spot for each injection.
  • Only use your APIDRA 3 mL cartridge system with OptiClik, a reusable insulin delivery device.
  • Use a new needle each time you give an APIDRA injection.
  • Use BD Ultra-Fine pen needles with the OptiClik. The needles do not come with the APIDRA 3 mL cartridge system or OptiClik. You will need to buy these from a pharmacy. Talk to your healthcare provider if you have questions.
  • Needles, OptiClik and cartridge systems must not be shared.

Getting ready

Make sure you have the following items:

  • OptiClik insulin delivery device
  • Pen needles
  • Alcohol swab
  • APIDRA cartridge system
  • Puncture resistant container. See “How do I dispose of used needles and cartridge systems?

Preparing for an injection

  • Wash your hands with soap and water before you start to touch the cartridge system or the OptiClik.
  • Use a new needle for each injection.
  • Always perform the safety test before use (see the OptiClik Instruction Leaflet).
  • Do not use APIDRA if the solution is colored, cloudy, or if you see particles in it.
  • Choose an injection area (for example upper arm, thigh, or stomach area). Change injection sites within the area you choose. Do not inject into the exact same spot for each injection.
  • After injecting APIDRA, leave the needle in the skin for at least 10 seconds. Then pull the needle straight out. Gently press the injection site for a few seconds. Do not rub the area.
  • Handle OptiClik® with care
  • Do not use OptiClik if it is damaged or if you are not sure that it is working correctly.

How do I dispose of used needles and cartridge systems?

  • Check with your healthcare provider for instructions about the right way to dispose of used needles and pens. There may be local or state laws about how to dispose of used needles and pens. Do not dispose of used needles or pens in household trash and do not recycle.
  • Put used needles and used empty cartridge systems in a container made specially for disposing of used syringes and needles (called a “sharps” container) or a hard plastic container (such as detergent bottles),with a screw-on cap, or metal container with a plastic lid labeled “Used Syringes”. These containers should be sealed and disposed of the right way.

How should I store APIDRA cartridge system?

  • Store the opened cartridge system in the OptiClik (Insulin Delivery Device) below 77°F (25°C). Do not refrigerate.
  • Keep away from direct heat and light.
  • Dispose of any used APIDRA cartridge system 28 days after the first use even if there is insulin left in the cartridge.

If your blood glucose reading is high or low, tell your healthcare provider so the dose can be changed.

If you have lost your OptiClik Instruction Leaflet or have a question, go to www.opticlik.com or call 1-800-633-1610.

Last reviewed on RxList: 9/23/2013
This monograph has been modified to include the generic and brand name in many instances.

A A A

Apidra - User Reviews

Apidra User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Apidra sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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