"Adding opicapone to levodopa therapy in patients with Parkinson's disease (PD) experiencing motor fluctuations reduces "off" time by almost an hour and increases "on" time, without affecting the rate of troublesome dyskinesia, according to "...
Apokyn Consumer (continued)
This drug should not be used with the following medications because very serious interactions may occur: certain drugs for nausea/bowel problems (5HT-3 antagonists such as alosetron, granisetron, ondansetron).
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting apomorphine.
Apomorphine may affect the heartbeat when used at higher doses. Many drugs besides apomorphine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using apomorphine, report all medications you are currently using to your doctor or pharmacist. .
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antipsychotics (e.g., chlorpromazine, haloperidol, thiothixene), certain drugs for nausea (e.g., metoclopramide, phenothiazines such as prochlorperazine), drugs for high blood pressure (e.g., beta blockers such as atenolol), vasodilators (e.g., nitrates), "water pills" (diuretics such as furosemide, thiazides).
Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., risperidone, amitriptyline, trazodone). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: very severe nausea/vomiting, loss of consciousness.
NOTES: Do not share this medication with others.
People with Parkinson's disease may have an increased risk for developing skin cancer (melanoma). Tell your doctor promptly if you notice a change in the appearance or size of moles or other unusual skin changes. Ask your doctor if you should have regular skin exams.
MISSED DOSE: Not applicable.
STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.
Syringes can be filled the night before use and stored in the refrigerator until the next day. Discard this type of pre-filled syringe if not used in 24 hours.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised October 2014. Copyright(c) 2014 First Databank, Inc.
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