August 24, 2016
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"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended the marketing of selexipag (Uptravi, Actelion Registration Ltd) for the treatment of adults with pulmonary arterial hypertension (PAH)./"...



Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

How Supplied


Essential hypertension, alone or as an adjunct.


Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2-4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.

The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses of Apresoline (hydralazine) .

In a few resistant patients, up to 300 mg of Apresoline (hydralazine) daily may be required for a significant antihypertensive effect. In such cases, a lower dosage of Apresoline (hydralazine) combined with a thiazide and/or reserpine or a beta blocker may be considered. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug.


Tablets 10 mg – round, pale yellow, dry-coated (imprinted CIBA 37)
   Bottles of 100 ........................... NDC 0083-0037-30
Tablets 25 mg – round, deep blue, dry-coated (imprinted CIBA 39)
    Bottles of 100 ........................... NDC 0083-0039-30
Tablets 50 mg – round, light blue, dry-coated (imprinted CIBA 73)
    Bottles of 100 ........................... NDC 0083-0073-30
Tablets 100 mg – round, peach, dry-coated (imprinted CIBA 101)
   Bottles of 100 ........................... NDC 0083-0101-30

Samples, when available, are identified by the word SAMPLE appearing on each tablet.

Do not store above 86°F (30 C).

Dispense in tight, light-resistant container (USP).

666692     C95-14 (Rev. 5-95)

Ciba-Geigy Corporaton
Pharmaceuticals Division
Summit, New Jersey 07901

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004

How Supplied

Apresoline - User Reviews

Apresoline User Reviews

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Here is a collection of user reviews for the medication Apresoline sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Get tips on handling your hypertension.