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(Generic versions may still be available.)
Apresoline Side Effects Center
Medical Editor: Melissa Conrad Stöppler, MD
Apresoline (hydralazine hydrochloride) is an antihypertensive drug indicated for treatment of hypertension by relaxing vascular smooth muscle. The brand name Apresoline is no longer available in the U.S. Generic versions may be available. Common side effects of Apresoline Hydrochloride include headache, anorexia, nausea, vomiting, loss of appetite, diarrhea, constipation, dizziness, anxiety, muscle or joint pain, runny or stuffy nose, or itching or skin rash.
Apresoline is administered orally in the form of tablets. Concurrent use of Apresoline with alcohol or other central nervous system depressants should be avoided because additional reductions in alertness and additional impairment of central nervous system performance may occur. In a few patients Apresoline may produce a clinical picture simulating systemic lupus erythematosus including glomerulonephritis. In such patients Apresoline should be discontinued unless the benefit-to-risk determination requires continued antihypertensive therapy with this drug. MAO inhibitors should be used with caution in patients receiving Apresoline. Apresoline should be used during pregnancy only if clearly needed.
Our Apresoline Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Apresoline in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- fast or pounding heartbeats;
- swelling in your face, stomach, hands, or feet;
- numbness, burning, pain, or tingly feeling;
- feeling like you might pass out;
- confusion, unusual thoughts or behavior;
- pale skin, easy bruising;
- painful or difficult urination;
- dark-colored urine;
- urinating less than usual or not at all; or
- joint pain or swelling with fever, chest pain, weakness or tired feeling.
Less serious side effects may include:
- nausea, vomiting, loss of appetite;
- diarrhea, constipation;
- muscle or joint pain;
- runny or stuffy nose; or
- mild itching or skin rash.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Apresoline (Hydralazine)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Apresoline Overview - Patient Information: Side Effects
To reduce the risk of dizziness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
This medication may infrequently cause nerve problems. Tell your doctor promptly if you experience numbness or tingling. Your doctor may recommend a vitamin B6 supplement (pyridoxine).
Tell your doctor immediately if any of these unlikely but serious side effects occur: severe tiredness, aching/swollen joints, rash on nose and cheeks, swollen glands, change in the amount of urine, bloody/pink urine, signs of infection (such as fever, chills, persistent sore throat), easy bruising/bleeding.
Seek immediate medical attention if this rare but serious side effect occurs: chest/jaw/left arm pain.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Apresoline (Hydralazine)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Apresoline FDA Prescribing Information: Side Effects
Adverse reactions with Apresoline (hydralazine) are usually reversible when dosage is reduced. However, in some cases it may be necessary to discontinue the drug. The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency.
Headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris.
Digestive: constipation, paralytic ileus.
Cardiovascular: hypotension, paradoxical pressor response, edema.
Neurologic: peripheral neuritis evidenced by paresthesia, numbness, and tingling, dizziness: tremors; muscle cramps; psychotic reactions characterized by depression, disorientation, or anxiety.
Genitourinary: difficulty in urination.
Hematologic: blood dyscrasias, consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, purpura, lymphadenopathy; splenomegaly.
Hypersensitive Reactions: rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, and, rarely, hepatitis.
Other: nasal congestion, flushing, lacrimation, conjunctivitis.
Read the entire FDA prescribing information for Apresoline (Hydralazine)
Additional Apresoline Information
Apresoline - User Reviews
Apresoline User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Get tips on handling your hypertension.