"The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has recommended 150 mg lamivudine/300 mg raltegravir (Dutrebis, Merck Sharp & Dohme Limited) for the treatment of HIV 1 infection in adults, adolesce"...
Aptivus Consumer (continued)
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.
This drug should not be used with the following medications because very serious interactions may occur: cisapride, pimozide, certain heart rhythm drugs (amiodarone, bepridil, flecainide, propafenone, quinidine), benzodiazepines (e.g., midazolam, triazolam), certain cholesterol-lowering drugs (atorvastatin, lovastatin, simvastatin), eletriptan, eplerenone, ergot-containing drugs (e.g., ergotamine), etravirine, ranolazine, certain drugs affecting liver enzymes that remove tipranavir from your body (rifampin, St. John's wort).
If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting tipranavir.
Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antiplatelet drugs (e.g., clopidogrel), artemether, "blood thinners" (anticoagulants such as warfarin, heparins), NSAIDs (e.g., ibuprofen, naproxen, sulindac, indomethacin), disulfiram, estrogens (e.g., ethinyl estradiol), garlic supplements, vitamin E, lumefantrine, metronidazole, drugs affecting liver enzymes that remove tipranavir from your body (such as atazanavir, certain anti-seizure medicines including carbamazepine/phenytoin, azole antifungals including fluconazole/itraconazole/ketoconazole, macrolide antibiotics including erythromycin).
Tipranavir can both speed up and slow down the removal of other drugs from your body, thereby affecting how they work. These affected drugs include (not a complete list): clarithromycin, fluticasone, omeprazole, salmeterol, temsirolimus, valproic acid, trazodone, calcium channel blockers such as felodipine, drugs that suppress the immune system such as cyclosporine/sirolimus/tacrolimus, certain narcotic pain medications such as meperidine/methadone, other HIV medications (such as etravirine, other protease inhibitors including fosamprenavir/lopinavir/saquinavir), other rifamycins including rifabutin, drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, vardenafil), antidepressants such as fluoxetine/sertraline/desipramine.
Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Talk to your doctor about additional or alternative reliable forms of birth control, and always use an effective barrier method (latex or polyurethane condoms/dental dams) during all sexual activity to decrease the risk of spreading HIV to others. Tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your hormonal birth control is not working well.
This document does not contain all possible interactions. Tipranavir is always given with ritonavir which also has many drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Do not share this medication with others.
Laboratory and/or medical tests (e.g., liver function tests, HIV RNA levels, blood sugar, blood counts, blood cholesterol/triglyceride levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Keep all medical and laboratory appointments.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: If you are using the capsules, refrigerate the unopened bottles between 36-46 degrees F (2-8 degrees C). Once opened, the capsules may be stored at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted.
If you are using the liquid form, store it at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not refrigerate or freeze the liquid.
For all forms of this drug, properly discard any unused medication 60 days after first opening the bottle. To help you remember when to discard unused medication, write the opening date on the bottle. Do not store in the bathroom. Keep all medicines away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised January 2014. Copyright(c) 2014 First Databank, Inc.
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