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In this Article

• What is tipranavir (Aptivus)?
• What are the possible side effects of tipranavir (Aptivus)?
• What is the most important information I should know about tipranavir (Aptivus)?
• What should I discuss with my health care provider before taking tipranavir (Aptivus)?
• How should I take tipranavir (Aptivus)?
• What happens if I miss a dose (Aptivus)?
• What happens if I overdose (Aptivus)?
• What should I avoid while taking tipranavir (Aptivus)?
• What other drugs will affect tipranavir (Aptivus)?
• Where can I get more information?

What happens if I miss a dose (Aptivus)?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Aptivus)?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a tipranavir overdose are unknown.

What should I avoid while taking tipranavir (Aptivus)?

If you also take didanosine, take it 2 hours before or after you take tipranavir.

Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect tipranavir (Aptivus)?

Many drugs can interact with tipranavir. Below is just a partial list. Tell your doctor if you are using:

• a blood thinner such as warfarin (Coumadin);
• disulfiram (Antabuse);
• enfuvirtide (Fuseon);
• fluticasone (Advair, Flonase, Flovent);
• insulin or diabetes medication you take by mouth;
• itraconazole (Sporanox) or ketoconazole (Nizoral);
• methadone (Methadose, Diskets, Dolophine);
• omeprazole (Prilosec);
• rifabutin (Mycobutin);
• vitamin E (especially at high doses);
• an antidepressant such as desipramine (Norpramin), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;
• a calcium channel blocker such as diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nicardipine (Cardene), nisoldipine (Sular), verapamil (Calan, Covera, Isoptin, Verelan);
• cholesterol-lowering medicine such as atorvastatin (Lipitor), rosuvastatin (Crestor), and others;
• drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
• medication used to prevent blood clots, such as clopidogrel (Plavix), dipyridamole (Persantine), and others;
• medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
• other HIV /AIDS medicine such as atazanavir (Reyataz), fosamprenavir (Lexiva), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase); or
• seizure medications such as carbamazepine (Carbatrol, Tegretol), clonazepam (Klonopin), divalproex (Depakote), ethosuximide (Zarontin), lamotrigine (Lamictal), phenobarbital (Solfoton), phenytoin (Dilantin), or valproic acid (Depakene).

This list is not complete and there are many other medicines that can interact with tipranavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about tipranavir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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