"The cystic fibrosis (CF) drug Orkambi (Vertex Pharmaceuticals) has received a green light from the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP).
Orkambi is a fixed-dose oral combination "...
(Generic versions may still be available.)
The pressor effect of ARAMINE (metaraminol) begins in 1 to 2 minutes after intravenous infusion, in about 10 minutes after intramuscular injection, and in 5 to 20 minutes after subcutaneous injection. The effect lasts from about 20 minutes to one hour. ARAMINE (metaraminol) has a positive inotropic effect on the heart and a peripheral vasoconstrictor action.
Renal, coronary, and cerebral blood flow are a function of perfusion pressure and regional resistance. In patients with insufficient or failing vasoconstriction, there is additional advantage to the peripheral action of ARAMINE (metaraminol) , but in most patients with shock, vasoconstriction is adequate and any further increase is unnecessary. Blood flow to vital organs may decrease with ARAMINE (metaraminol) if regional resistance increases excessively.
The pressor effect of ARAMINE (metaraminol) is decreased but not reversed by alpha-adrenergic blocking agents. Primary or secondary fall in blood pressure and tachyphylactic response to repeated use are uncommon.
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Aramine Information
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