"Today, the U.S. Food and Drug Administration approved Xuriden (uridine triacetate), the first FDA-approved treatment for patients with hereditary orotic aciduria. Hereditary orotic aciduria is a rare metabolic disorder, which has been reported in"...
(Generic versions may still be available.)
Overdosage may result in severe hypertension accompanied by headache, constricting sensation in the chest, nausea, vomiting, euphoria, diaphoresis, pulmonary edema, tachycardia, bradycardia, sinus arrhythmia, atrial or ventricular arrhythmias, cerebral hemorrhage, myocardial infarction, cardiac arrest or convulsions.
Should an excessive elevation of blood pressure occur, it may be immediately relieved by a sympatholytic agent, e.g. phentolamine. An appropriate antiarrhythmic agent may also be required.
The oral LD50 in the rat and mouse is 240 mg/kg and 99 mg/kg, respectively.
Use of ARAMINE (metaraminol) with cyclopropane or halothane anesthesia should be avoided, unless clinical circumstances demand such use.
Hypersensitivity to any component of this product, including sulfites (see WARNINGS).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Aramine Information
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