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Sympathomimetic amines, including ARAMINE (metaraminol) , may cause sinus or ventricular tachycardia, or other arrhythmias, especially in patients with myocardial infarction. (See PRECAUTIONS.)

In patients with a history of malaria, these compounds may provoke a relapse.

Abscess formation, tissue necrosis, or sloughing rarely may follow the use of ARAMINE (metaraminol) . In choosing the site of injection, it is important to avoid those areas recognized as not suitable for use of any pressor agent and to discontinue the infusion immediately if infiltration or thrombosis occurs. Although the physician may be forced by the urgent nature of the patient's condition to choose injection sites that are not recognized as suitable, he should, when possible, use the preferred areas of injection. The larger veins of the antecubital fossa or the thigh are preferred to veins in the dorsum of the hand or ankle veins, particularly in patients with peripheral vascular disease, diabetes mellitus, Buerger's disease, or conditions with coexistent hypercoagulability.

ARAMINE (metaraminol) should be used with caution in digitalized patients, since the combination of digitalis and sympathomimetic amines may cause ectopic arrhythmias.

Monoamine oxidase inhibitors or tricyclic antidepressants may potentiate the action of sympathomimetic amines. Therefore, when initiating pressor therapy in patients receiving these drugs, the initial dose should be small and given with caution. (See WARNINGS.)

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.