home > drugs a-z list > aranesp (darbepoetin alfa) drug center > aranesp (darbepoetin alfa) drug - medication guide and patient information

MEDICATION GUIDE

Aranesp®
(Air-uh-nesp)
(darbepoetin alfa)

Read this Medication Guide:

• before you start Aranesp,
• if you are told by your healthcare provider that there is new information about Aranesp,
• if you are told by your healthcare provider that you may inject Aranesp at home, read this Medication Guide each time you receive a new supply of medicine.

This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or your treatment. Talk with your healthcare provider regularly about the use of Aranesp and ask if there is new information about Aranesp.

What is the most important information I should know about Aranesp?

Using Aranesp can lead to death or other serious side effects.

For patients with cancer:

Your healthcare provider has received special training through the ESA APPRISE Oncology Program in order to prescribe Aranesp. Before you can begin to receive Aranesp, you must sign the patient-healthcare provider acknowledgment form. When you sign this form, you are stating that your healthcare provider talked with you about the risks of taking Aranesp.

These risks include that your tumor may grow faster and you may die sooner if you choose to take Aranesp. You should talk with your healthcare provider about:

• Why Aranesp treatment is being prescribed for you.
• What are the chances you will get red blood cell transfusions if you do not take Aranesp.
• What are the chances you will get red blood cell transfusions even if you take Aranesp.
• How taking Aranesp may affect the success of your cancer treatment.

After you have finished your chemotherapy course, Aranesp treatment should be stopped.

For all patients who take Aranesp, including patients with cancer or chronic kidney disease:

• If you decide to take Aranesp, your healthcare provider should prescribe the smallest dose of Aranesp that is needed to reduce your chance of getting red blood cell transfusions.
• You may get serious heart problems such as heart attack, stroke, heart failure, and may die sooner if you are treated with Aranesp to reach a normal or near-normal hemoglobin level.
• You may get blood clots at any time while taking Aranesp. If you are receiving Aranesp for any reason and you are going to have surgery, talk to your healthcare provider about whether or not you need to take a blood thinner to lessen the chance of blood clots during or following surgery. Clots can form in blood vessels (veins), especially in your leg (deep venous thrombosis or DVT). Pieces of a blood clot may travel to the lungs and block the blood circulation in the lungs (pulmonary embolus).

Call your healthcare provider or get medical help right away if you have any of these symptoms of blood clots:

• Chest pain
• Trouble breathing or shortness of breath
• Pain in your legs, with or without swelling
• A cool or pale arm or leg
• Sudden confusion, trouble speaking, or trouble understanding others' speech
• Sudden numbness or weakness in your face, arm, or leg, especially on one side of your body
• Sudden trouble seeing
• Sudden trouble walking, dizziness, loss of balance or coordination
• Loss of consciousness (fainting)
• Hemodialysis vascular access stops working

See "What are the possible side effects of Aranesp?" below.

What is Aranesp?

Aranesp is a man-made form of the protein human erythropoietin that is given to reduce or avoid the need for red blood cell transfusions. Aranesp stimulates your bone marrow to make more red blood cells. Having more red blood cells raises your hemoglobin level. If your hemoglobin level stays too high or if your hemoglobin goes up too quickly, this may lead to serious health problems which may result in death. These serious health problems may happen even if you take Aranesp and do not have an increase in your hemoglobin level.

Aranesp may be used to treat a lower than normal number of red blood cells (anemia) if it is caused by:

• Chronic kidney disease (you may or may not be on dialysis).
• Chemotherapy that will be used for at least two months after starting Aranesp.

Aranesp should not be used for the treatment of anemia:

• If you have cancer and you will not be receiving chemotherapy that may cause anemia for at least 2 more months.
• If you have a cancer that has a high chance of being cured.
• In place of emergency treatment for anemia (red blood cell transfusions).

Aranesp has not been proven to improve the quality of life, fatigue, or well-being.

Who should not take Aranesp?

Do not take Aranesp if you:

• Have cancer and have not been counseled by your healthcare provider regarding the risks of Aranesp or if you have not signed the patient-healthcare provider acknowledgment form before you start Aranesp treatment.
• Have high blood pressure that is not controlled (uncontrolled hypertension).
• Have been told by your healthcare provider that you have or have ever had a type of anemia called Pure Red Cell Aplasia (PRCA) that starts after treatment with Aranesp or other erythropoietin protein medicines.
• Have had a serious allergic reaction to Aranesp.

What should I tell my healthcare provider before taking Aranesp?

Aranesp may not be right for you. Tell your healthcare provider about all your health conditions, including if you:

• Have heart disease.
• Have high blood pressure.
• Have had a seizure (convulsion) or stroke.
• Are allergic to latex.
• Have any other medical conditions.
• Are pregnant or planning to become pregnant. It is not known if Aranesp may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you.

If you are pregnant, discuss with your healthcare provider about enrolling in Amgen's Pregnancy Surveillance Program or call 1-800-772-6436 (l-800-77-AMGEN).

• Are breast-feeding or planning to breast-feed. It is not known if Aranesp passes into breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Know the medicines you take. Keep a list of your medicines with you and show it to your healthcare provider when you get a new medicine.

How should I take Aranesp?

See "What is the most important information I should know about Aranesp?"

For patients with cancer:

Before you begin to receive Aranesp, your healthcare provider will:

• Ask you to review this Aranesp Medication Guide.
• Explain the risks of Aranesp and answer all your questions about Aranesp.
• Have you sign the patient-healthcare provider acknowledgment form.

For all patients who take Aranesp:

• Continue to follow your healthcare provider's instructions for diet, and medicines, including medicines for high blood pressure, while taking Aranesp.
• Have your blood pressure checked as instructed by your healthcare provider.
• If you or your caregiver has been trained to give Aranesp shots (injections) at home:
  • Be sure that you read, understand, and follow the "Instructions for Use" that come with Aranesp.
  • Take Aranesp exactly as your healthcare provider tells you to. Do not change the dose of Aranesp unless told to do so by your healthcare provider.
  • Your healthcare provider will show you how much Aranesp to use, how to inject it, how often it should be injected, and how to safely throw away the used vials, syringes, and needles.
  • If you miss a dose of Aranesp, call your healthcare provider right away and ask what to do.
  • If you take more than the prescribed amount of Aranesp, call your healthcare provider right away.

What are the possible side effects of Aranesp?

Aranesp may cause serious side effects.

• See "What is the most important information I should know about Aranesp?"
• High blood pressure. High blood pressure is a common side effect of Aranesp in patients with chronic kidney disease. Your blood pressure may go up or be difficult to control with blood pressure medicine while taking Aranesp. This can happen even if you have never had high blood pressure before. Your healthcare provider should check your blood pressure often. If your blood pressure does go up, your healthcare provider may prescribe new or more blood pressure medicine.
• Seizures. If you have any seizures while taking Aranesp, get medical help right away and tell your healthcare provider.
• Antibodies to Aranesp. Your body may make antibodies to Aranesp. These antibodies can block or lessen your body's ability to make red blood cells and cause you to have severe anemia. Call your healthcare provider if you have unusual tiredness, lack of energy, dizziness, or fainting. You may need to stop taking Aranesp.
• Serious allergic reactions. Serious allergic reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness and fainting because of a drop in blood pressure, swelling around your mouth or eyes, fast pulse, or sweating. If you have a serious allergic reaction, stop using Aranesp and call your healthcare provider or get medical help right away.

The needle cover on the prefilled syringe contains latex. If you know you are allergic to latex, talk to your healthcare provider before using Aranesp.

Common side effects of Aranesp include:

• shortness of breath
• cough
• low blood pressure during dialysis
• abdominal pain
• edema (swelling) of the arms or legs

These are not all of the possible side effects of Aranesp. Your healthcare provider can give you a more complete list. Tell your healthcare provider about any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Aranesp?

• Do not shake Aranesp.
• Protect Aranesp from light.
• Store Aranesp in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Do not freeze Aranesp. Do not use Aranesp that has been frozen.
• Throw away the Aranesp vial or prefilled syringe after one use. Do not re-use even if there is medicine left.

Keep Aranesp and all medicines out of the reach of children. General information about Aranesp

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Use Aranesp only for the condition for which it has been prescribed. Do not give Aranesp to other patients even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Aranesp. If you would like more information about Aranesp, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about Aranesp that is written for healthcare professionals. For more information, go to the following website: www.aranesp.com or call 1-800-77-AMGEN.

What are the ingredients in Aranesp?

Active Ingredient: darbepoetin alfa
Inactive Ingredients: polysorbate 80, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous, and sodium chloride in Water for Injection, USP.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Instructions for Use

Aranesp®
(Air-uh-nesp)
(darbepoetin alfa) Single-Dose Prefilled Syringe (SingleJect®)

Use these Instructions for Use if you or your caregiver has been trained to give Aranesp injections at home. Do not give yourself the injection unless you have received training from your healthcare provider. If you are not sure about giving the injection or if you have questions, ask your healthcare provider for help.

Before reading these Instructions for Use, read the Medication Guide that comes with Aranesp for the most important information you need to know.

When you receive your Aranesp prefilled syringe make sure that:

• The name Aranesp appears on the carton and prefilled syringe label.
• The expiration date on the prefilled syringe label has not passed. Do not use a prefilled syringe of Aranesp after the expiration date on the label.
• The dose strength of the Aranesp prefilled syringe (number of micrograms [mcg] in the colored square on the package and on the prefilled syringe label) is the same as your healthcare provider prescribed.
• The Aranesp liquid in the prefilled syringe is clear and colorless. Do not use Aranesp if the liquid in the prefilled syringe looks discolored or cloudy, or if the liquid has lumps, flakes, or particles.
• Do not use Aranesp in a prefilled syringe if the grey cover on the needle is off, or the needle guard (clear yellow plastic sleeve on the syringe) has been pulled to extend over the needle (activated).
• Do not shake Aranesp. Shaking could cause Aranesp not to work. If you shake Aranesp the solution may look foamy and it should not be used.
• Do not freeze Aranesp. Do not use an Aranesp prefilled syringe that has been frozen.
• Store Aranesp in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Keep Aranesp away from light.

How should I prepare for an injection of Aranesp?

Follow your healthcare provider's instructions on how to measure your dose of Aranesp. This dose will be measured in milliliter (mL) or cc (1 mL is the same as 1 cc).

Use the prefilled syringe only one time and throw it away as instructed by your healthcare provider.

Important: Follow these instructions exactly to help avoid infections.

Preparing the dose:

1. Remove one prefilled syringe from the refrigerator. During this time, protect the prefilled syringe from light. Keep the prefilled syringe in its wrapper until you are ready to prepare your dose. Do not leave the prefilled syringe in light.

2. Use each Aranesp prefilled syringe only one time.

3. Do not shake Aranesp.

4. Gather the other supplies you will need for your injection (prefilled syringe with a clear yellow plastic needle guard attached, alcohol wipes, cotton ball, and a puncture-proof container for throwing away the prefilled syringe). See Figure 1.

Figure 1

5. Check the date on the label on your Aranesp prefilled syringe to be sure that the drug has not expired.

6. Wash your hands well with soap and water before preparing the medicine. See Figure 2.

Figure 2

7. Open the package and remove the syringe from the tray. Check to see that the needle cover is on and the yellow needle guard is covering the barrel of the syringe. If the needle guard is covering the needle, then it has already been activated. Do not use that syringe. Throw away the syringe in the puncture-proof disposable container. Use a new syringe. Do not slide the needle guard over the needle cover before injection. This will “activate” or lock the needle guard.

8. Hold the syringe with the needle pointing up to prevent the Aranesp from leaking out of the needle. Carefully pull the needle cover straight off. See Figure 3.

Figure 3

9. Check the syringe for air bubbles. If there are air bubbles, gently tap the syringe with your fingers until the air bubbles rise to the top of the syringe. Slowly push the plunger up to force the air bubbles out of the syringe. See Figure 4.

Figure 4

10. Keep holding the syringe up. Slowly push the plunger to the line on the syringe that matches the dose your healthcare provider has prescribed.

11. Check again to make sure that you have the correct dose in the syringe.

12. When you put the syringe down on your work surface, be careful not to let the needle touch anything.

Selecting and preparing the injection site:

Aranesp can be injected into your body using two different ways (routes) as described below. Follow your healthcare provider's instructions about how you should inject Aranesp. For patients on hemodialysis, the intravenous (IV) route is recommended.

1. Subcutaneous Route:

• Aranesp can be injected directly into a layer of fat under your skin. This is called a subcutaneous injection. When giving subcutaneous injections, follow your healthcare provider's instructions about changing the site for each injection. You may wish to write down the site where you have injected.
• Do not inject Aranesp into an area that is tender, red, bruised, hard, or has scars or stretch marks. Recommended sites for injection are shown in Figure 5 below, including:
  • The outer area of the upper arms
  • The abdomen (except for the 2-inch area around the navel)
  • The front of the middle thighs
  • The upper outer area of your buttocks

Figure 5

• Clean the skin with an alcohol wipe where the injection is to be made. Be careful not to touch the skin that has been wiped clean. See Figure 6.

Figure 6

• Hold the prefilled syringe in the hand that you will use to inject the medicine.
• Use the other hand to pinch a fold of skin at the cleaned injection site. Do not touch the cleaned area of skin. See Figure 7. Note: Hold the syringe barrel through the two needle guard windows when giving the injection.

Figure 7

• Hold the syringe like you would hold a pencil. Use a quick “dart-like” motion to insert the needle either straight up and down (90-degree angle) or at a slight angle (45 degrees) into the skin. Inject the prescribed dose subcutaneously as directed by your doctor, nurse, or pharmacist. See Figure 8.

Figure 8

• Pull the needle out of the skin and press a cotton ball or gauze over the injection site and hold it there for several seconds. Do not recap the needle.
• Dispose of the used prefilled syringe as described below. Do not reuse the prefilled syringe.

2. Intravenous Route :

• Aranesp can be injected in your vein through a special access port placed by your healthcare provider. This type of Aranesp injection is called an intravenous (IV) injection. This route is usually for hemodialysis patients.
• If you have a dialysis vascular access, make sure it is working by checking it as your healthcare provider has shown you. Be sure to let your healthcare provider know right away if you are having any problems, or if you have any questions.
• Wipe off the venous port of the hemodialysis tubing with an alcohol wipe. See Figure 9.

Figure 9

• Insert the needle of the prefilled syringe into the cleaned venous port and push the plunger all the way down to inject all the Aranesp. See Figure 10.

Figure 10

• Remove the prefilled syringe from the venous port. Do not recap the needle.
• Dispose of the used prefilled syringe as described below. Do not reuse the prefilled syringe.

Activation of the needle guard on used prefilled syringes

After injecting Aranesp from the prefilled syringe, do not recap the needle. Keep your hands behind the needle at all times. To activate the needle guard, hold the finger grip of the syringe with one hand and grasp the needle guard with your free hand. Slide the needle guard completely over the needle until the needle guard clicks into place. See Figures 11 and 12. NOTE: If you do not hear a click, the needle guard may not be completely activated.

Figure 11

Figure 12

How should I dispose of the prefilled syringe?

• Do not reuse the prefilled syringe. Throw away the prefilled syringe with the activated needle guard as directed by your healthcare provider or by following these steps:
• Do not throw the prefilled syringes in the household trash or recycle.
• Do not put the needle cover back on the needle.
• Place the used prefilled syringe in a puncture-proof disposable container with a lid. Do not use glass or clear plastic containers, or any container that will be recycled or returned to a store.
• Keep the puncture-proof disposable container out of the reach of children.
• When the puncture-proof disposable container is full, tape around the cap or lid to make sure the cap or lid does not come off. Throw away the puncture-proof disposable container as instructed by your healthcare provider. There may be special state and local laws for disposing of used prefilled syringes. Do not throw the puncture-proof disposable container in the household trash. Do not recycle.

Keep Aranesp and all medicines out of reach of children.

These Instructions for Use have been approved by the U.S. Food and Drug Administration

Aranesp®
(Air-uh-nesp)
(darbepoetin alfa) Single-Dose Vial

Use these Instructions for Use if you or your caregiver has been trained to give Aranesp injections at home. Do not give yourself the injection unless you have received training from your healthcare provider. If you are not sure about giving the injection or if you have questions, ask your healthcare provider for help.

Before reading these Instructions for Use, read the Medication Guide that comes with Aranesp for the most important information you need to know.

When you receive your Aranesp vial and syringes make sure that:

• The name Aranesp appears on the carton and vial label.
• The expiration date on the vial label has not passed. Do not use a vial of Aranesp after the expiration date on the label.
• The dose strength of the Aranesp vial (number of micrograms [mcg] in the colored square on the package and on the vial label) is the same as your healthcare provider prescribed.
• The Aranesp liquid in the vial is clear and colorless. Do not use Aranesp if the liquid in the vial looks discolored or cloudy, or if the liquid has lumps, flakes, or particles.
• The Aranesp vial has a color cap on the top of the vial. Do not use a vial of Aranesp if the color cap on the top of the vial has been removed or is missing.
• Use only the type of disposable syringe and needle that your healthcare provider has prescribed.
• Do not shake Aranesp. Shaking could cause Aranesp not to work. If you shake Aranesp, the solution in the vial may look foamy and should not be used.
• Do not freeze Aranesp. Do not use a vial of Aranesp that has been frozen.
• Store Aranesp in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Keep Aranesp away from light.
• Single-dose vials of Aranesp should be used only one time. Throw the vial away after use even if there is medicine left in the vial.

How should I prepare for an injection of Aranesp?

• Always keep an extra syringe and needle on hand.
• Follow your healthcare provider's instructions on how to measure your dose of Aranesp. This dose will be measured in milliliter (mL) or cc (1 mL is the same as 1 cc). Use a syringe that is marked in tenths of mL (for example, 0.2 mL or 0.2 cc). Using the wrong syringe can lead to a mistake in your dose and you could inject too much or too little Aranesp.

Only use disposable syringes and needles. Use the syringes and needles only one time and then throw them away as instructed by your healthcare provider.

Important: Follow these instructions exactly to help avoid infections.

Preparing the dose:

1. Remove the vial of Aranesp from the refrigerator. During this time, protect the solution from light. Keep the vial in its carton until you are ready to prepare the dose. Do not leave the vial in light.

2. Do not use a single-dose vial of Aranesp more than one time.

3. Do not shake Aranesp.

4. Gather the other supplies you will need for your injection (vial, syringe, alcohol wipes, cotton ball, and a puncture-proof container for throwing away the syringe and needle). See Figure 1.

Figure 1

5. Check the date on the Aranesp vial to be sure that the drug has not expired.

6. Wash your hands well with soap and water before preparing the medicine. See Figure 2.

Figure 2

7. Flip off the protective color cap on the top of the vial. Do not remove the grey rubber stopper. Wipe the top of the grey rubber stopper with an alcohol wipe. See Figures 3 and 4.

Figure 3

Figure 4

8. Check the package containing the syringe. If the package has been opened or damaged, do not use that syringe. Throw away the syringe in the puncture-proof disposable container. If the syringe package is undamaged, open the package and remove the syringe.

9. Using a syringe and needle that has been recommended by your healthcare provider, carefully remove the needle cover. See Figure 5. Then draw air into the syringe by pulling back on the plunger. The amount of air drawn into the syringe should be equal to the amount (mL or cc) of the Aranesp dose prescribed by your healthcare provider. See Figure 6.

Figure 5

Figure 6

10. With the vial on a flat work surface, insert the needle straight down through the grey rubber stopper of the Aranesp vial. See Figure 7.

11. Push the plunger of the syringe down to inject the air from the syringe into the vial of Aranesp. The air injected into the vial will allow Aranesp to be easily withdrawn into the syringe. See Figure 7.

Figure 7

12. Keep the needle inside the vial. Turn the vial and syringe upside down. Be sure the tip of the needle is in the Aranesp liquid. Keep the vial upside down. Slowly pull back on the plunger to fill the syringe with Aranesp liquid to the number (mL or cc) that matches the dose your healthcare provider prescribed. See Figure 8.

Figure 8

13. Keep the needle in the vial. Check for air bubbles in the syringe. A small amount of air is harmless. Too large an air bubble will give you the wrong Aranesp dose. To remove air bubbles, gently tap the syringe with your fingers until the air bubbles rise to the top of the syringe. Slowly push the plunger up to force the air bubbles out of the syringe. Keep the tip of the needle in the Aranesp liquid. Pull the plunger back to the number on the syringe that matches your dose. Check again for air bubbles. If there are still air bubbles, repeat the steps above to remove them. See Figures 9 and 10.

Figure 9

Figure 10

14. Double-check that you have the correct dose in the syringe. Lay the vial down on its side with the needle still in it until after you have selected and prepared a site for injection.

Selecting and preparing the injection site:

Aranesp can be injected into your body using two different ways (routes) as described below. Follow your healthcare provider's instructions about how you should inject Aranesp. For patients on hemodialysis, the intravenous (IV) route is recommended.

1. Subcutaneous Route:

• Aranesp can be injected directly into a layer of fat under your skin. This is called a subcutaneous injection. When giving subcutaneous injections, follow your healthcare provider's instructions about changing the site for each injection. You may wish to write down the site where you have injected.
• Do not inject Aranesp into an area that is tender, red, bruised, hard, or has scars or stretch marks. Recommended sites for injection are shown in Figure 11 below, including:
  • The outer area of the upper arms
  • The abdomen (except for the 2-inch area around the navel)
  • The front of the middle thighs
  • The upper outer area of the buttocks

Figure 11

• Clean the skin with an alcohol wipe where the injection is to be made. Be careful not to touch the skin that has been wiped clean. See Figure 12.

Figure 12

• Double-check that the correct amount of Aranesp is in the syringe.
• Remove the prepared syringe and needle from the vial of Aranesp and hold it in the hand that you will use to inject the medicine.
• Use the other hand to pinch a fold of skin at the cleaned injection site. Do not touch the cleaned area of skin. See Figure 13.

Figure 13

• Hold the syringe like you would hold a pencil. Use a quick “dart-like” motion to insert the needle either straight up and down (90-degree angle) or at a slight angle (45 degrees) into the skin. Inject the prescribed dose subcutaneously as directed by your doctor, nurse, or pharmacist. See Figure 14.

Figure 14

• Pull the needle out of the skin and press a cotton ball or gauze over the injection site and hold it there for several seconds. Do not recap the needle.
• Dispose of the used syringe and needle as described below. Do not reuse syringes and needles.

2. Intravenous Route :

• Aranesp can be injected in your vein through a special access port placed by your healthcare provider. This type of Aranesp injection is called an intravenous (IV) injection. This route is usually for hemodialysis patients.
• If you have a dialysis vascular access, make sure it is working by checking it as your healthcare provider has shown you. Be sure to let your healthcare provider know right away if you are having any problems, or if you have any questions.
• Wipe off the venous port of the hemodialysis tubing with an alcohol wipe. See Figure 15.

Figure 15

Insert the needle of the syringe into the cleaned venous port and push the plunger all the way down to inject all the Aranesp. See Figure 16.

Figure 16

• Remove the syringe from the venous port. Do not recap the needle.
• Dispose of the used syringe and needle as described below.

How should I dispose of the vials, syringes, and needles?

Do not reuse the single-dose vials, syringes, or needles. Throw away the vials, syringes, and needles as instructed by your healthcare provider or by following these steps:

• Do not throw the vials, syringes, or needles in the household trash or recycle.
• Do not put the needle cover back on the needle.
• Place all used needles and syringes in a puncture-proof disposable container with a lid. Do not use glass or clear plastic containers, or any container that will be recycled or returned to a store.
• Keep the puncture-proof disposable container out of the reach of children.
• When the puncture-proof disposable container is full, tape around the cap or lid to make sure the cap or lid does not come off. Throw away the puncture-proof disposable container as instructed by your healthcare provider. There may be special state and local laws for disposing of used needles and syringes. Do not throw the puncture-proof disposable container in the household trash. Do not recycle.

Keep Aranesp and all medicines out of reach of children.

These Instructions for Use have been approved by the U.S. Food and Drug Administration.

Last reviewed on RxList: 6/29/2011
This monograph has been modified to include the generic and brand name in many instances.