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home > drugs a-z list > aranesp (darbepoetin alfa) drug center > aranesp (darbepoetin alfa) drug - overdosage and contraindications
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Aranesp
What are the kidneys?
The kidneys play key roles in body function, not only by filtering the blood and getting rid of waste products, but also by balancing levels of electrolyte levels in the body, controlling blood pressure, and stimulating the production of red blood cells.
The kidneys are located in the abdomen toward the back, normally one on each side of the spine. They get their blood supply through the renal arteries directly from the aorta and send blood back to the heart via the renal veins to the vena cava. (The term "renal" is derived from the Latin name for kidney.)
The kidneys have the ability to monitor the amount of body fluid, the concentrations of electrolytes like sodium and potassium, and the acid-base balance of the body. They filter waste products of body metabolism, like urea from protein metabolism and uric acid from DNA breakdown. Two waste products in the blood can be measured: blood urea nitrogen (BUN) ...
Aranesp
OVERDOSE
Aranesp overdosage can cause hemoglobin levels above the desired level, which should be managed with discontinuation or reduction of Aranesp dosage and/or with phlebotomy, as clinically indicated [see Pharmacodynamics]. Cases of severe hypertension have been observed following overdose with ESAs [see WARNINGS AND PRECAUTIONS].
CONTRAINDICATIONS
Aranesp is contraindicated in patients with:
- Uncontrolled hypertension [see WARNINGS AND PRECAUTIONS].
- Pure red cell aplasia (PRCA) that begins after treatment with Aranesp or other erythropoietin protein drugs [see WARNINGS AND PRECAUTIONS].
- Serious allergic reactions to Aranesp [see WARNINGS AND PRECAUTIONS].
Last reviewed on RxList: 6/29/2011
This monograph has been modified to include the generic and brand name in many instances.
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