April 26, 2017
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Arcalyst Patient Information including How Should I Take

What should I discuss with my healthcare provider before using rilonacept (Arcalyst)?

You should not use this medication if you are allergic to rilonacept, or if you have any type of infection.

To make sure rilonacept is safe for you, tell your doctor if you have any of these conditions:

  • an active or chronic infection;
  • a history of tuberculosis or recurrent infections; or
  • high cholesterol or triglycerides (a type of fat in blood).

Make sure you are current on all vaccines before you start treatment with rilonacept.

Using rilonacept may increase your risk of developing certain types of cancer. Talk with your doctor about your specific risk.

FDA pregnancy category C. It is not known whether rilonacept will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether rilonacept passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not give this medicine to a child younger than 12 years old without medical advice.

How is rilonacept given (Arcalyst)?

Follow the directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Rilonacept is injected under the skin. You may be shown how to use injections at home. Use exactly as prescribed by your doctor. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Your first dose may be given in two injections at a time, each on a different place on your body.

Rilonacept is a powder medicine that must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Use a different place on your stomach, thigh, or upper arm each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

While using rilonacept, you may need frequent blood tests at your doctor's office.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Store the unmixed powder medicine in the refrigerator and protected from light. Do not freeze. Keep each vial in the original container until you are ready to mix your medicine.

After mixing rilonacept with a diluent, store at room temperature and use it within 3 hours. Protect from light.

Side Effects Centers

Additional Arcalyst Information

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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