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Argatroban

"A drug candidate developed by researchers at the NIH's National Center for Advancing Translational Sciences (NCATS) and its collaborators to treat sickle cell disease has been acquired by Baxter International's BioScience business. The drug c"...

Argatroban

ARGATROBAN
Injection

DRUG DESCRIPTION

Argatroban is a synthetic direct thrombin inhibitor and the chemical name is 1-[5-[(aminoiminomethyl) amino]-1-oxo2[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2- piperidinecarboxylic acid, monohydrate. Argatroban has 4 asymmetric carbons. One of the asymmetric carbons has an R configuration (stereoisomer Type I) and an S configuration (stereoisomer Type II). Argatroban consists of a mixture of R and S stereoisomers at a ratio of approximately 65:35.

The molecular formula of argatroban is C23H36N6O5S•H2O. Its molecular weight is 526.66 g/mol. The structural formula is:

Argatroban Structural Formula Illustration

Argatroban Injection is a sterile, non-pyrogenic, clear, colorless to pale yellow, aqueous solution. It is supplied in a single use, clear glass vial containing 50 mg of argatroban in 50 mL solution. Each mL, contains 1 mg argatroban, 2 mg lactobionic acid, 2 mg L-methionine USP, 8 mg sodium chloride USP, and sodium hydroxide NF (for pH adjustment) in water for injection USP. The pH of the solution is approximately 8.8.

What are the possible side effects of argatroban (Acova)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • blood in your urine;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • any bleeding that will not stop;
  • pain or...

Read All Potential Side Effects and See Pictures of Argatroban »

What are the precautions when taking argatroban injection (Argatroban)?

Consult your...

Read All Potential Precautions of Argatroban »

Last reviewed on RxList: 8/10/2011
This monograph has been modified to include the generic and brand name in many instances.

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Argatroban - User Reviews

Argatroban User Reviews

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