Arimidex (Anastrozole) Drug Information: Overdosage and Contraindications

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May 24, 2012

Arimidex

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Breast cancer is the most common cancer among American women.
One in every eight women in the United States develops breast cancer.
There are many types of breast cancer that differ in their capability of spreading (metastasize) to other body tissues.
The causes of breast cancer are not yet fully known although a number of risk factors have been identified.
There are many different types of breast cancer.
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Treatment of breast cancer depends on the type of cancer and its stage (the extent of spread in the body).

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Over 200,000 new cases of invasive breast cancer are diagnosed each year.
Nearly 40,000 women will die of breast cancer in 2011.
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OVERDOSE

Clinical trials have been conducted with ARIMIDEX (anastrozole) , up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were tolerated. A single dose of ARIMIDEX (anastrozole) that results in life-threatening symptoms has not been established. There is no specific antidote to overdosage and treatment must be symptomatic. In the management of an overdose, consider that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because ARIMIDEX (anastrozole) is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.

CONTRAINDICATIONS

Pregnancy and Premenopausal Women

ARIMIDEX (anastrozole) may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. ARIMIDEX (anastrozole) is contraindicated in women who are or may become pregnant. There are no adequate and well- controlled studies in pregnant women using ARIMIDEX (anastrozole) . If ARIMIDEX (anastrozole) is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus or potential risk for loss of the pregnancy. [see Use in Specific Populations]

Hypersensitivity

ARIMIDEX (anastrozole) is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or to any of the excipients. Observed reactions include anaphylaxis, angioedema, and urticaria. [see ADVERSE REACTIONS]

Last reviewed on RxList: 12/2/2010
This monograph has been modified to include the generic and brand name in many instances.