Arimidex
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Arimidex
OVERDOSE
Clinical trials have been conducted with ARIMIDEX (anastrozole) , up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were tolerated. A single dose of ARIMIDEX (anastrozole) that results in life-threatening symptoms has not been established. There is no specific antidote to overdosage and treatment must be symptomatic. In the management of an overdose, consider that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because ARIMIDEX (anastrozole) is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.
CONTRAINDICATIONS
Pregnancy and Premenopausal Women
ARIMIDEX (anastrozole) may cause fetal harm when administered to a pregnant woman and offers no clinical benefit to premenopausal women with breast cancer. ARIMIDEX (anastrozole) is contraindicated in women who are or may become pregnant. There are no adequate and well- controlled studies in pregnant women using ARIMIDEX (anastrozole) . If ARIMIDEX (anastrozole) is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus or potential risk for loss of the pregnancy. [see Use in Specific Populations]
Hypersensitivity
ARIMIDEX (anastrozole) is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or to any of the excipients. Observed reactions include anaphylaxis, angioedema, and urticaria. [see ADVERSE REACTIONS]
Last reviewed on RxList: 12/2/2010
This monograph has been modified to include the generic and brand name in many instances.
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