Arixtra (Fondaparinux Sodium) Drug Information: Overdosage and Contraindications

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May 24, 2012

Arixtra

Pulmonary Embolism (Blood Clot in the Lung) »

What is a pulmonary embolism?

The lungs are a pair of organs in the chest that are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and blood. The lung is composed of clusters of small air sacs (alveoli) divided by thin, elastic walls (membranes). Capillaries, the tiniest of blood vessels, run within these membranes between the alveoli and allow blood and air to come near each other. The distance between the air in the lungs and the blood in the capillaries is very small, and allows molecules of oxygen and carbon dioxide to transfer across the membranes.

The exchange of the air between the lungs and blood are through the arterial and venous system. Arteries and veins both carry and move blood throughout the body, but the process for each is very different.

Arteries carry blood from the heart to the body.
Veins return blood from the body to the heart.
The heart i...

Read the Pulmonary Embolism (Blood Clot in the Lung) article »

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Arixtra User Reviews >>

Arixtra

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OVERDOSE

There is no known antidote for ARIXTRA (fondaparinux sodium) . Overdose of ARIXTRA (fondaparinux sodium) may lead to hemorrhagic complications. Discontinue treatment and initiate appropriate therapy if bleeding complications associated with overdosage occur.

Data obtained in patients undergoing chronic intermittent hemodialysis suggest that clearance of ARIXTRA (fondaparinux sodium) can increase by 20% during hemodialysis.

CONTRAINDICATIONS

ARIXTRA (fondaparinux sodium) is contraindicated in the following conditions:

Severe renal impairment (creatinine clearance [CrCl] < 30 mL/min). [See WARNINGS AND PRECAUTIONS and Use in Specific Populations.]
Active major bleeding.
Bacterial endocarditis.
Thrombocytopenia associated with a positive in vitro test for anti-platelet antibody in the presence of fondaparinux sodium.
Body weight < 50 kg (venous thromboembolism [VTE] prophylaxis only) [see WARNINGS AND PRECAUTIONS].

Last reviewed on RxList: 4/15/2010
This monograph has been modified to include the generic and brand name in many instances.