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Asacol HD

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Asacol HD

OVERDOSE

There is no specific antidote for mesalamine overdose and treatment for suspected acute severe toxicity with Asacol HD (mesalamine delayed-release tablets, oral) should be symptomatic and supportive. This may include prevention of further gastrointestinal tract absorption, correction of fluid electrolyte imbalance, and maintaining adequate renal function. Asacol HD (mesalamine delayed-release tablets, oral) is a pH dependent delayed release product and this factor should be considered when treating a suspected overdose.

Single oral doses of 5000 mg/kg mesalamine suspension in mice (approximately 4.2 times the recommended human dose of Asacol HD (mesalamine delayed-release tablets, oral) based on body surface area), 4595 mg/kg in rats (approximately 7.8 times the recommended human dose of Asacol HD (mesalamine delayed-release tablets, oral) based on body surface area) and 3000 mg/kg in cynomolgus monkeys (approximately 10 times the recommended human dose of Asacol HD based on body surface area) were lethal.

CONTRAINDICATIONS

Asacol HD (mesalamine delayed-release tablets, oral) is contraindicated in patients with hypersensitivity to salicylates or aminosalicylates or to any of the components of Asacol HD (mesalamine delayed-release tablets, oral) tablets.

Last reviewed on RxList: 10/23/2009
This monograph has been modified to include the generic and brand name in many instances.

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