November 29, 2015


(polidocanol) Injection, for Intravenous use


Asclera (polidocanol injection) is a sterile, nonpyrogenic, and colorless to faintly greenish-yellow solution of polidocanol for intravenous use as a sclerosing agent.

The active ingredient, polidocanol is a non-ionic detergent, consisting of two components, a polar hydrophilic (dodecyl alcohol) and an apolar hydrophobic (polyethylene oxide) chain. Polidocanol has the following structural formula:

Asclera (polidocanol) Structural Formula Illustration

C12H25(OCH2CH2)nOH      Polyethylene glycol monododecyl ether

Mean extent of polymerization (n) : Approximately 9
Mean molecular weight : Approximately 600

Each mL contains 5 mg (0.5%) or 10 mg (1.0%) polidocanol in water for injection with 5% (v/v) ethanol at pH 6.5-8.0; disodium hydrogen phosphate dihydrate, potassium dihydrogen phosphate are added for pH adjustment.

What are the possible side effects of laureth-9 (Asclera)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; sneezing, runny nose, difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have a serious side effect such as:

  • severe pain, burning, or other irritation in your leg;
  • discoloration or skin changes where an injection was given;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • severe numbness that does not go away;
  • pain, swelling, warmth, or redness in one or both...

Read All Potential Side Effects and See Pictures of Asclera »

Last reviewed on RxList: 4/16/2010
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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