Asclera (polidocanol injection) is a sterile, nonpyrogenic, and colorless to faintly greenish-yellow solution of polidocanol for intravenous use as a sclerosing agent.

The active ingredient, polidocanol is a non-ionic detergent, consisting of two components, a polar hydrophilic (dodecyl alcohol) and an apolar hydrophobic (polyethylene oxide) chain. Polidocanol has the following structural formula:

C₁₂H₂₅(OCH₂CH₂)_nOH      Polyethylene glycol monododecyl ether

Mean extent of polymerization (n) : Approximately 9
Mean molecular weight : Approximately 600

Each mL contains 5 mg (0.5%) or 10 mg (1.0%) polidocanol in water for injection with 5% (v/v) ethanol at pH 6.5-8.0; disodium hydrogen phosphate dihydrate, potassium dihydrogen phosphate are added for pH adjustment.

Last reviewed on RxList: 4/16/2010
This monograph has been modified to include the generic and brand name in many instances.